REMODULIN Struktur

REMODULIN

Bezeichnung:REMODULIN

CAS-Nr81846-19-7

Englisch Name:REMODULIN

CBNumberCB7231250

SummenformelC23H34O5

Molgewicht390.51

MOL-Datei81846-19-7.mol

REMODULIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	121-123°
Siedepunkt	587.1±50.0 °C(Predicted)
Dichte	1.158±0.06 g/cm3(Predicted)
storage temp.	Sealed in dry,Store in freezer, under -20°C
Löslichkeit	Chloroform (Slightly, Heated), Methanol (Slightly, Heated)
Aggregatzustand	Solid
pka	3.19±0.10(Predicted)
Farbe	Off-White to Beige

Gefahreninformationscode (GHS)

REMODULIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Synthetic analog of Prostacyclin (P839060). Antihypertensive. Treprostinil, marketed under the trade name Remodulin is a medication used to treat pulmonary arterial hypertension (PAH).
Definition
ChEBI: Treprostinil is a carboxylic acid and a carbotricyclic compound. It has a role as a platelet aggregation inhibitor, a vasodilator agent, an antihypertensive agent, a cardiovascular drug, a vitamin K antagonist and a human blood serum metabolite.
Pharmakokinetik
Treprostinil is rapidly absorbed from the subcutaneous site of infusion, with an almost 100% bioavailability and a mean half-life of 85 minutes (34 minutes for the IV infusion). The IV solution must be diluted with normal saline or sterile water before starting the infusion. Unlike epoprostenol, treprostinil is stable at room temperature for up to 5 years, with vasodilation action lasting from 4 to 6 hours, compared with the short, 2- to 3-minute action for epoprostenol. Because of its long life in the body, it can be administered under the skin with a microinfusion subcutaneous infusion pump rather than into the bloodstream and, thus, without hospitalization, as contrasted with the central IV infusion of epoprostenol.
Clinical Use
Treprostinil is a synthetic, stable form of prostacyclin for the treatment for advanced pulmonary hypertension with NYHA class III or IV symptoms as well as for late-stage peripheral vascular disease (PVD). Its sodium salt injectable form is administered either as a continuous subcutaneous infusion directly into the skin or, if the subcutaneous infusion is not tolerated, as a continuous IV infusion without an implanted catheter.
Nebenwirkungen
Side effects include jaw pain, headaches, nausea, diarrhea, flushing, and localized pain at the delivery site under the skin. This pain has been reported as slight to severe irritation. Patients using the drug seem to ex-perience improvement in their condition, including decreased fatigue, decreased shortness of breath, and decreased pulmonary artery pressures, as well as overall improvement in quality of life.
Lager
Store at -20°C

REMODULIN Upstream-Materialien And Downstream Produkte

REMODULIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

81846-19-7, REMODULIN Verwandte Suche:

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