4-Aminobiphenyl

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H350：Kann Krebs verursachen.

• Sicherheit

  P201：Vor Gebrauch besondere Anweisungen einholen.

  P202：Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.

  P264：Nach Gebrauch gründlich waschen.

  P264：Nach Gebrauch gründlich waschen.

  P270：Bei Gebrauch nicht essen, trinken oder rauchen.

  P301+P312：BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.

  P308+P313：BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

4-Aminobiphenyl Chemische Eigenschaften,Einsatz,Produktion Methoden

• ERSCHEINUNGSBILD

  FARBLOSER FESTSTOFF IN VERSCHIEDENEN FORMEN MIT CHARAKTERISTISCHEM GERUCH. VERFäRBT SICH VIOLETT BEI KONTAKT MIT LUFT.

• CHEMISCHE GEFAHREN

  Beim Verbrennen Bildung giftiger Gase. Schwache Base in wässriger Lösung. Reagiert mit starken Oxidationsmitteln.

• ARBEITSPLATZGRENZWERTE

  TLV: Hautresorption Krebskategorie A1(bestätigte krebserzeugende Wirkung beim Menschen); (ACGIH 2005).
  MAK: Hautresorption; Krebserzeugend Kategorie 1; (DFG 2005).
  

• AUFNAHMEWEGE

  Aufnahme in den Körper durch Inhalation, über die Haut und durch Verschlucken.

• INHALATIONSGEFAHREN

  Verdampfung bei 20°C vernachlässigbar; eine gesundheitsschädliche Partikelkonzentration in der Luft kann jedoch beim Dispergieren schnell erreicht werden.

• WIRKUNGEN BEI KURZZEITEXPOSITION

  WIRKUNGEN BEI KURZZEITEXPOSITION:
  Die Substanz reizt die Augen. Möglich sind Auswirkungen auf die Blase mit nachfolgendem Blut im Urin.

• WIRKUNGEN NACH WIEDERHOLTER ODER LANGZEITEXPOSITION

  Krebserzeugend für den Menschen.

• LECKAGE

  Verschüttetes Material in abdichtbaren Behältern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Reste sorgfältig sammeln. An sicheren Ort bringen. Persönliche Schutzausrüstung: Vollschutzanzug mit umgebungsluftunabhängigem Atemschutzgerät.

• R-Sätze Betriebsanweisung:

  R45:Kann Krebs erzeugen.
  R22:Gesundheitsschädlich beim Verschlucken.
  R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
  R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.

• S-Sätze Betriebsanweisung:

  S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
  S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.

• Aussehen Eigenschaften

  C12H11N. (p-Phenylanilin, 4-Biphenylamin). Farblose Kristalle

• Gefahren für Mensch und Umwelt

  Die Substanz kann durch die Haut aufgenommen werden. Erzeugt beim Menschen nach chronischer Exposition Harnblasenkarzinome. Die Latenzzeit für das Auftreten von Blasenkrebs beträgt 15-35 Jahre. Inhalation führt zu Kopfschmerz und Lethargie. Toxische Wirkung auf Leber und Niere.
  Kann Krebs erzeugen.

• Schutzmaßnahmen und Verhaltensregeln

  Verwendung möglichst vermeiden. Ersatzstoffprüfung. Hautkontakt und Staubbildung vermeiden.
  Schutzhandschuhe (nur kurzzeitiger Spritz- und Staubschutz).

• Verhalten im Gefahrfall

  Verschüttete Substanz unter Vermeidung von Staubbildung vorsichtig aufnehmen und als Sonderabfall entsorgen.
  Pulverlöscher, Wasser, Schaum.
  Bei Aufräumungsarbeiten Hautkontakt vermeiden. Beim Erhitzen der Substanz bilden sich giftige Gase.

• Erste Hilfe

  Nach Hautkontakt: Betroffene Hautpartien mit viel Wasser und Seife gründlich waschen.
  Nach Augenkontakt: Ausgiebige Spülung (mindestens 15 Minuten) mit viel Wasser (evtl. Kontaktlinsen entfernen). Augenarzt!
  Nach Einatmen: Frischluft. Arzt!
  Nach Verschlucken: Erbrechen auslösen. Aktivkohle geben.
  Nach Kleidungskontakt: Benetzte Kleidung sofort ausziehen. Betroffenen Körperteile mit viel Wasser und Seife gründlich reinigen.
  Ersthelfer: siehe gesonderten Anschlag

• Sachgerechte Entsorgung

  Transportgerecht verpackt und vollständig deklariert als Sondermüll abliefern.

• Beschreibung

  4-Aminobiphenyl is an aromatic amine (arylamine) that exists at room temperature as a colorless crystalline solid with a floral odor. It is slightly soluble in cold water, but readily soluble in hot water. It is soluble in ethanol, ether, acetone, chloroform, and lipids. It oxidizes in air and emits toxic fumes when heated to decomposition (Akron 2009).

• Physikalische Eigenschaften

  Colorless to yellow-brown crystalline solid with a floral-like odor. Becomes purple on exposure to air.

• Verwenden

  Previously used as a rubber antioxidant; no longer produced on a commercial scale

• Verwenden

  In the detection of sulfates. Formerly as rubber antioxidant. As carcinogen in cancer research, induces chromosomal instability in human cancer cells.

• Verwenden

  In the United States, 4-aminobiphenyl now is used only in laboratory research. It formerly was used commercially as a rubber antioxidant, as a dye intermediate, and in the detection of sulfates (HSDB 2009).

• Definition

  ChEBI: 4-Aminobiphenyl is an aminobiphenyl that is biphenyl substituted by an amino group at position 4. It has a role as a carcinogenic agent. It derives from a hydride of a biphenyl.

• Synthesis Reference(s)

  Journal of the American Chemical Society, 97, p. 7184, 1975 DOI: 10.1021/ja00857a049
  Tetrahedron Letters, 39, p. 1313, 1998 DOI: 10.1016/S0040-4039(97)10877-2

• Allgemeine Beschreibung

  Colorless to yellowish-brown crystals or light brown solid.

• Air & Water Reaktionen

  Is oxidized by air (darkens on oxidation). Insoluble in water.

• Reaktivität anzeigen

  4-AMINOBIPHENYL is a weak base. Incompatible with acids and acid anhydrides. Forms salts with hydrochloric acid and sulfuric acid. Can be diazotized, acetylated and alkylated. . May react with strong oxidizing agents.

• Hazard

  Toxic by ingestion, inhalation, skin absorp- tion. Confirmed carcinogen. Bladder and liver can- cer.

• Health Hazard

  4-Aminodiphenyl exposure is associated with a high incidence of bladder cancer in humans.

• Brandgefahr

  4-AMINOBIPHENYL is probably combustible.

• Sicherheitsprofil

  Confirmed human carcinogen with experimental carcinogenic and tumorigenic data. Poison by ingestion and intraperitoneal routes. Human mutation data reported. An irritant. Effects resemble those of benzidine. See also BENZIDINE. Slight to moderate fire hazard when exposed to heat, flames (sparks), or powerful oxidzers. To fight fire, use water spray, mist, dry chemical. When heated to decomposition it emits toxic fumes of NOx,. See also AROMATIC AMINES.

• Synthese

  4-aminobiphenyl is prepared by reduction of 4-nitrobiphenyl, which, together with the 2-nitro derivatives, is obtained by nitration of biphenyl.

• mögliche Exposition

  4-Aminobiphenyl is no longer manufactured commercially and is only used for research purposes. 4-Aminobiphenyl was formerly used as a rubber antioxidant and as a dye intermediate. Is a contaminant in 2-aminobiphenyl.

• Carcinogenicity

  4-Aminobiphenyl is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.
  Cancer of the urinary bladder was first reported to be associated with occupational exposure to 4-aminobiphenyl in a descriptive epidemiological study (published in the mid 1950s), in which 11% (19 of 171) of workers in a plant manufacturing 4-aminobiphenyl developed urinary-bladder cancer. These workers had been exposed to 4-aminobiphenyl for 1.5 to 19 years between 1935 and 1955. Publication of this study led to an effort to discontinue production and useof 4-aminobiphenyl. Starting in 1955, 541 workers who had been exposed to 4-aminobiphenyl were followed for an additional 14 years; 43 men (7.9%) developed histologically confirmed urinary-bladder cancer. In a survey of workers at a plant producing a variety of chemicals, the risk of mortality from urinary-bladder cancer was elevated tenfold, and all of the men who died of urinary-bladder cancer had worked at the plant during the period when 4-aminobiphenyl was used (1941 through 1952). The International Agency for Research onCancer concluded that there was sufficient evidence of the carcinogenicity of 4-aminobiphenyl in humans (IARC 1972, 1987).
  Since 4-aminobiphenyl was listed in the First Annual Report on Carcinogens, most research on its carcinogenicity has focused on exposure from cigarette smoking. Epidemiological studies have reported the incidence of urinary-bladder cancer to be 2 to 10 times as high among cigarette smokers as among nonsmokers. Higher levels of 4-aminobiphenyl adducts (4-aminobiphenyl metabolites bound to DNA or protein) were detected in bladder tumors (DNA adducts) and red blood cells (hemoglobin adducts) from smokers thanfrom nonsmokers (Feng et al. 2002). In a case-control study, levels of 4-aminobiphenyl–hemoglobin adducts were higher in smokers with urinary-bladder cancer than in a control group of similarly exposed smokers (Del Santo et al. 1991). A Taiwanese study reported that 4-aminobiphenyl–hemoglobin adducts were associated with increased risk of liver cancer (Wang et al. 1998).

• Environmental Fate

  4-Aminobiphenyl is one of a number of chemicals that cause methemoglobinemia, or conversion of hemoglobin to methemoglobin, which reduces the ability of the blood to carry oxygen to the tissues. In addition, the active metabolite is believed to produce cancer through its reaction with cellular DNA. In animal studies, the observed incidence of 4-aminobiphenyl adducts with bladder epithelium DNA correlated well with the observed bladder tumor incidence.

• Stoffwechselwegen

  Ring oxidation of 4-aminobiphenyl occurred only to a minor extent in microsomes. In contrast, N-oxidation of 4,4'-methylene-bis-(2-chloroaniline) is preferentially catalyzed by the phenobarbital-induced enzymes P- 450PB-B and P-450PB-D to cause ring oxidation and methylene carbon oxidation. 4,4'-Methylene-bis-(2- chloroaniline) ring oxidation and methylene carbon oxidation show varied cytochrome P-450 selectivity and accounted for 14-79% of total oxidation products.

• Versand/Shipping

  UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required. UN3143 Dyes, solid, toxic, n.o.s. or Dye intermediates, solid, toxic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required

• läuterung methode

  Crystallise it from water or EtOH. [Beilstein 12 IV 3241.] CARCINOGENIC.

• Toxicity evaluation

  4-Aminobiphenyl may have been released into the environment during its production and use as a rubber antioxidant and dye intermediate; however, sources suggest that it was no longer in significant production by the early 1970s. 4-Aminobiphenyl is easily oxidizable and probably undergoes photolysis but there is little actual data on these processes. If released on land it is expected to adsorb moderately to soil, probably binding to humic materials, and undergo redox reactions. If released to surface water, it is expected to adsorb to sediment, and probably undergo photolysis and oxidation. It may be degraded by oxidation by alkoxy radicals, which are photochemically produced in eutrophic waters, with an estimated half-life of 14 days. 4-Aminobiphenyl is biodegradable and biodegradation may well occur in both soil and water but there are no rates available for soil or surface waters. It has a low potential for bioconcentration. In the atmosphere, degradation should occur due to direct photolysis, oxidation by ambient oxygen, and photochemically produced hydroxyl radicals (estimated half-life 6–7 h in the vapor phase).

• Inkompatibilitäten

  Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides and acid anhydrides.

• Waste disposal

  Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contaminant (≥100 kg/mo) must conform with EPA regulations governing storage, transportation, treatment, and waste disposal. Controlled incineration whereby oxides of nitrogen are removed from the effluent gas by scrubber, catalytic or thermal devices.

4-Aminobiphenyl Upstream-Materialien And Downstream Produkte

4-Aminobiphenyl Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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