erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride

erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Chemische Eigenschaften

  White to Off-White Solid

• Verwenden

  A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does not inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM). Potent PDE-2 inhibitor.

• Verwenden

  EHNA hydrochloride has been used to treat microexplant culture to examine the direction and the motor responsible for the movement of autophagosomes in axons. It has also been used in nucleoside supplementation to inhibit the breakdown of deoxyadenosine by the enzyme adenosine deaminase.

• Verwenden

  A potent inhibitor of phosphodiesterase II (PDE II) (IC50=800nM). Does ot inhibit other PDE isozymes (IC50>100uM). Inhibits the retrograde transport motor, dynein. Also inhibits adenosine deaminase (Ki=4nM).

• Definition

  ChEBI: (2R,3S)-EHNA hydrochloride is a hydrochloride salt obtained by reaction of (2R,3S)-EHNA with one equivalent of hydrochloric acid. Selective inhibitor of cGMP-stimulated phosphodiesterase (PDE2) (IC50 = 0.8 - 4 mM). Also a potent inhibitor of adenosine deaminase. It has a role as an EC 3.1.4.* (phosphoric diester hydrolase) inhibitor and an EC 3.5.4.4 (adenosine deaminase) inhibitor. It contains a (2R,3S)-EHNA(1+).

• Allgemeine Beschreibung

  EHNA is an adenosine deaminase inhibitor. It possesses antitumor action.

• Lager

  Room temperature

erythro-9-(2-Hydroxy-3-nonyl)adenine hydrochloride, erythro-9-Amino-β-hexyl-α-methyl-9H-purine-9-ethanol hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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