Anti-Der1-like domain family, member 3, Anti-DERL3

Anti-Der1-like domain family, member 3, Anti-DERL3 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Anti-Derlin-3 antibody produced in rabbit has been used in immunoblotting, immunoprecipitation, and immunofluorescence.

• Biologische Aktivität

  Derlin-3 is involved in the degradation of misfolded glycoproteins in the ER. Derlin-3 shares ~30% sequence identity with Derlin-1 and spans the lipid bilayer of the ER four times, showing structural similarity to Derlin-1. It is a component of the mammalian ER-associated degradation (ERAD) mechanism and is upregulated by unfolded protein response (UPR). Overexpression of this gene leads to increase in degradation of misfolded glycoprotein, whereas its knockdown blocks degradation. Derlin-3 also interacts with the mammalian orthologs of the yeast Hrd1p/Hrd3p ubiquitin-ligase complex.

Anti-Der1-like domain family, member 3, Anti-DERL3 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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