Diphenylchlorphosphat

Bezeichnung:Diphenylchlorphosphat

CAS-Nr2524-64-3

Englisch Name:Diphenyl chlorophosphate

CBNumberCB7198748

SummenformelC12H10ClO3P

Molgewicht268.63

MOL-Datei2524-64-3.mol

Synonyma

Diphenylchlorphosphat

Diphenylchlorphosphat physikalisch-chemischer Eigenschaften

Siedepunkt	314-316 °C/272 mmHg (lit.)
Dichte	1.296 g/mL at 25 °C (lit.)
Dampfdruck	10 mm Hg ( 190 °C)
Brechungsindex	n20/D 1.55(lit.)
Flammpunkt	>230 °F
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly)
Aggregatzustand	Liquid
Farbe	Clear colorless to light yellow
Wasserlöslichkeit	MAY DECOMPOSE
Sensitive	Moisture Sensitive
BRN	654130
Stabilität	Stable under recommended storage conditions., Stable Under Recommended Storage C
CAS Datenbank	2524-64-3(CAS DataBase Reference)
NIST chemische Informationen	Diphenyl chlorophosphate(2524-64-3)
EPA chemische Informationen	Phosphorochloridic acid, diphenyl ester (2524-64-3)

Sicherheit

Kennzeichnung gefährlicher	C
R-Sätze:	34-37
S-Sätze:	26-36/37/39-45-7-24/25-23
RIDADR	UN 3265 8/PG 2
WGK Germany	3
TSCA	Yes
HazardClass	8
PackingGroup	III
HS Code	29209085

Gefahreninformationscode (GHS)

Diphenyl chlorophosphate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R34:Verursacht Verätzungen.
R37:Reizt die Atmungsorgane.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
S7:Behälter dicht geschlossen halten.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S23:Gas/Rauch/Dampf/Aerosol nicht einatmen(geeignete Bezeichnung(en) vom Hersteller anzugeben).
Verwenden
Diphenyl chlorophosphate is used to prepare cyclohexyl-amidophosphoric acid diphenyl ester by reacting with cyclohexylamine. It is also used in the synthesis of alfa-substituted beta-lactams, anhydrides, esters and thioesters. It is also employed in the conversion of aldoximes to nitriles. Further, it is used in the preparation and reaction of enol phosphates, guanosine-adenosine-5',5'-triphosphate, guanosine-cytidine-5',5'-triphosphate, guanosine-uridine-5',5'-triphosphate, diguanosine-5',5'-diphosphate and diguanosine-5',5'-triphosphate. In addition to this, it serves as a phosphorylating agent for the preparation of 2-deoxy-D-galactose-3 and -6 phosphoric acids.
Verwenden
Diphenyl chlorophosphate may be used:
- in the preparation of guanosine-adenosine-5′,5′-triphosphate, guanosine-cytidine-5′,5′-triphosphate, guanosine-uridine-5′,5′-triphosphate, diguanosine-5′,5′-diphosphate and diguanosine-5′,5′-triphosphate
- as phosphorylating agent for the synthesis of 2-deoxy-D-galactose-3 and -6 phosphoric acids
- in the synthesis of diaryl phosphoryl derivatives of alkylene dithiophosphates
synthetische
The preparation of Diphenyl chlorophosphate is as follows:With a thermometer,Reflux condenser and mechanical agitation120 g of dichloromethane was placed in a 500 ml four-neck reaction flask.7.3 g of N,N-dimethylformamide,Stirring temperature control below 10 °C,Put 28g of bis(trichloromethyl) carbonate,A solution of 50 g of diphenyl phosphate and 120 g of dichloromethane was added.After the addition, the reaction was carried out for 3 hours. After the end of the reaction, the temperature was controlled below 10 ° C, 20 g of water was slowly added, and the mixture was stirred and the organic phase was dried over anhydrous sodium sulfate. The desiccant was removed by filtration, and the filtrate was evaporated under normal pressure. The temperature was lowered to 0 ° C, and the insoluble matter was removed by filtration to obtain 48.9 g of diphenyl chlorophosphate. The purity of GC was 99.2%, and the yield was 90.3%.
Allgemeine Beschreibung
A clear colorless to light yellow liquid with a pungent odor. Insoluble in water and denser than water. Hence sinks in water. Contact may severely irritate skin, eyes and mucous membranes. Flash point above 235°F.
Air & Water Reaktionen
Insoluble in water.
Reaktivität anzeigen
Diphenyl chlorophosphate is incompatible with bases (including amines) strong oxidizing agents, and alcohols. May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291]. May form highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
Health Hazard
TOXIC; inhalation, ingestion or skin contact with material may cause severe injury or death. Contact with molten substance may cause severe burns to skin and eyes. Avoid any skin contact. Effects of contact or inhalation may be delayed. Fire may produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Brandgefahr
Non-combustible, substance itself does not burn but may decompose upon heating to produce corrosive and/or toxic fumes. Some are oxidizers and may ignite combustibles (wood, paper, oil, clothing, etc.). Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated.
läuterung methode
Fractionally distil it in 30 351.5490. a good vacuum; better use a spinning band column. [Walsh J Am Chem Soc 81 3023 1959, IR: Bellamy & Beecher J Chem Soc 475 1952, Beilstein 6 IV 737.]

Diphenyl chlorophosphate Upstream-Materialien And Downstream Produkte

Diphenylchlorphosphat Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2524-64-3, Diphenyl chlorophosphate Verwandte Suche:

Send Inquriy