2-Amino-4-chloropyridine

Bezeichnung:2-Amino-4-chloropyridine

CAS-Nr19798-80-2

Englisch Name:2-Amino-4-chloropyridine

CBNumberCB7183078

SummenformelC5H5ClN2

Molgewicht128.56

MOL-Datei19798-80-2.mol

2-Amino-4-chloropyridine physikalisch-chemischer Eigenschaften

Schmelzpunkt	126-127°C
Siedepunkt	240.8±20.0 °C(Predicted)
Dichte	1.326±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	DMSO, Methanol
Aggregatzustand	Liquid
pka	5.72±0.11(Predicted)
Farbe	Colorless to yellow to brown
maximale Wellenlänge (λmax)	294nm(CHCl3)(lit.)
Sensitive	Air & Moisture Sensitive
InChI	InChI=1S/C5H5ClN2/c6-4-1-2-8-5(7)3-4/h1-3H,(H2,7,8)
InChIKey	RQMWVVBHJMUJNZ-UHFFFAOYSA-N
SMILES	C1(N)=NC=CC(Cl)=C1
CAS Datenbank	19798-80-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	22-36/37/38
S-Sätze:	26
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333990

Gefahreninformationscode (GHS)

2-Amino-4-chloropyridine Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
Light yellow Cryst
Verwenden
2-Amino-4-chloropyridine is a useful precursor that could be used to synthesize 2-amino-4,5-dichloropyridine, 2-amino-3,4-dichloropyridine, and 2-amino-3,4,5-trichloropyridine[1].
Synthesis Reference(s)
The Journal of Organic Chemistry, 72, p. 4554, 2007 DOI: 10.1021/jo070189y
Synthese
Methyl 4-chloropicolinate hydrochloride in methanol was treated with hydrazine hydrate, resulting in the formation of a precipitate. The suspension was then stirred for 2 hours and the precipitated hydrazide was collected through filtration. The hydrazide was dissolved in 1N hydrochloric acid and the solution was cooled to a temperature between 0-5 ℃. A solution of sodium nitrite in water was then added dropwise, causing another precipitate to form. After stirring for 15 minutes, the precipitate was collected by filtration and washed with water. The moist precipitate was then combined with a mixture of acetic acid and water, and the resulting solution was heated in a steam bath until gas evolution stopped. The reaction mixture was cooled to room temperature, the pH was adjusted to 7, and the resulting precipitate was collected via filtration. Recrystallization using ethanol yielded 2-Amino-4-chloropyridine in the form of a white crystalline solid[1].
Einzelnachweise
[1] Gudmundsson, Kristjan S. , et al. "An Improved Large Scale Synthesis of 2-Amino-4-chloropyridine and Its Use for the Convenient Preparation of Various Polychlorinated 2-Aminopyridines." Synthetic Communications 27.5(1997):861-870.

2-Amino-4-chloropyridine Upstream-Materialien And Downstream Produkte

2-Amino-4-chloropyridine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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