Pyridin-3,4-dicarbonsure

Bezeichnung:Pyridin-3,4-dicarbonsure

CAS-Nr490-11-9

Englisch Name:3,4-Pyridinedicarboxylic acid

CBNumberCB7143667

SummenformelC7H5NO4

Molgewicht167.12

MOL-Datei490-11-9.mol

Synonyma

Pyridin-3,4-dicarbonsure

Pyridin-3,4-dicarbonsure physikalisch-chemischer Eigenschaften

Schmelzpunkt	262 °C (dec.) (lit.)
Siedepunkt	295.67°C (rough estimate)
Dichte	1.5216 (rough estimate)
Brechungsindex	1.6280 (estimate)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	2.34g/l
pka	1.00±0.10(Predicted)
Aggregatzustand	Fine Crystalline Powder
Farbe	White to slightly beige
Wasserlöslichkeit	2.34g/L(25 ºC)
Merck	14,2283
BRN	137242
InChI	InChI=1S/C7H5NO4/c9-6(10)4-1-2-8-3-5(4)7(11)12/h1-3H,(H,9,10)(H,11,12)
InChIKey	MUYSADWCWFFZKR-UHFFFAOYSA-N
SMILES	C1=NC=CC(C(O)=O)=C1C(O)=O
CAS Datenbank	490-11-9(CAS DataBase Reference)
NIST chemische Informationen	3,4-Pyridinedicarboxylic acid(490-11-9)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36-24/25
WGK Germany	3
HazardClass	IRRITANT
HS Code	29333999
Speicherklasse	11 - Combustible Solids
Hazard Classifications	Eye Irrit. 2 Skin Irrit. 2 STOT SE 3

Gefahreninformationscode (GHS)

3,4-Pyridinedicarboxylic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to slightly beige fine crystalline powder
Definition
ChEBI: Cinchomeronic acid is a pyridinedicarboxylic acid. It is a conjugate acid of a cinchomeronate(1-).
Synthese
750 g (5.55 mol) of concentrated sulfuric acid and 1.4 g (0.175 mol) of selenium powder were heated in a four-necked flask equipped with a stirrer, a thermometer, a dropping cylinder, and a large gas outlet tube. Once the temperature reached 275 degrees Celsius, the selenium dissolved in concentrated sulfuric acid. 1 g (0.125 mol) of selenium powder was dissolved in 50 g (0.37 mol) of sulfuric acid, briefly heated to 275 degrees Celsius, cooled to room temperature and then combined with 129.2 g (1 mol) of isoquinoline solution dissolved in 550 g (4.08 mol) of sulfuric acid, and dropped into the sulfuric acid with a dropping cartridge to maintain the temperature of the reaction process at 270-280 degrees Celsius. During implementation, water vapor and sulfur dioxide were passed through a gas discharge tube and extracted through a funnel placed above using a water jet pump. After about 2l /2 hours, the entire solution was added drop by drop and the temperature was maintained between 270 - 280C for another hour. After cooling the mixture to room temperature, 400 ml of water was added and 5 g of activated carbon was added and boiled for a few minutes. The selenium and activated charcoal were filtered off and the cooled orange-yellow solution was carefully adjusted with concentrated ammonia to a pH of 1.5. After standing for a few hours, the precipitate was filtered off and washed with water to obtain 3,4-pyridinedicarboxylic acid.
läuterung methode
Crystallise the acid from H2O or dilute aqueous HCl. It has also been purified via the dimethyl ester which is distilled (b 95-100o/1.5mm) and hydrolysed with 3.5N HCl, evaporated and recrystallised. [Armarego & Evans J Appl Chem 12 45 1962, Foye et al. J Med Chem 9 61 1966, Beilstein 22 H 155, 22 I 534, 22 II 106, 22 III/IV 1641, 22/4 V 135.]

3,4-Pyridinedicarboxylic acid Upstream-Materialien And Downstream Produkte

Pyridin-3,4-dicarbonsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

490-11-9, 3,4-Pyridinedicarboxylic acid Verwandte Suche:

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