CpG ODN 10101

CpG ODN 10101 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  CpG ODN 10101, a synthetic oligodeoxynucleotide (ODN),? is a toll-like receptor 9 (TLR9) agonist. CpG ODN 10101 is a potent inducer of cytokine/chemokine expression ex vivo when used in combination with HH2(VQLRIRVAVIRA-NH2). CpG ODN 10101 induces IFN- secretion from dendritic cells (DCs) and stimulates B-cells.CpG ODN 10101 has antiviral and immunomodulatory properties that can influence chronic infection with HCV[1][2].

• IC 50

  TLR9

• Einzelnachweise

  [1] Jason Kindrachuk, et al. A novel vaccine adjuvant comprised of a synthetic innate defence regulator peptide and CpG oligonucleotide links innate and adaptive immunity. Vaccine. 2009 Jul 23;27(34):4662-71. DOI:10.1016/j.vaccine.2009.05.094
  [2] John G McHutchison, et al. Phase 1B, randomized, double-blind, dose-escalation trial of CPG 10101 in patients with chronic hepatitis C virus. Hepatology. 2007 Nov;46(5):1341-9. DOI:10.1002/hep.21773

CpG ODN 10101 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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