NSC63925 Struktur

NSC63925

Bezeichnung:NSC63925

CAS-Nr20261-85-2

Englisch Name:NSC63925

CBNumberCB71251059

SummenformelC42H68O12

Molgewicht764.98

MOL-Datei20261-85-2.mol

NSC63925 physikalisch-chemischer Eigenschaften

storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	film

NSC63925 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Dinactin is a macrotetrolide antibiotic that acts as an ionophore for monovalent cations, such as K⁺, NH₄⁺, and Rb⁺. It is commonly used to study membrane properties. Dinactin is a component of a macrotetralide-rich antifungal mixture produced by Streptomyces. Dinactin inhibits T-cell proliferation and cytokine production in vitro and reduces pulmonary eosinophilia in antigen-challenged mice.
Verwenden
Dinactin is a hydrophobic cyclic ester that inhibits T-cell proliferation induced by IL-2.
Verwenden
Dinactin is a member of the macrotetrolide complex produced by a range of Streptomyces species. It is a monovalent cation ionophore with high selectivity for ammonium and potassium. Dinactin inhibits T-cell proliferation induced by IL-2 and cytokine production at nanomolar levels for IL-2, IL-4, IL-5 and interferon-γ. Dinactin has not previously been available for intensive investigation.
in vitro
dinactin inhibited t-cell proliferation induced by il-2, by mab to cd3, and by mabs to cd3 plus α-cd28 with identical dose-response curves. the ic50 was 10–20 ng/ml. dinactin inhibited cytokine production with ic50 values of 10 ng/ml for il-4 and il-5, 30 or 60 ng/ml for interferong or il-2, respectively [3].dinactin inhibited cytokine production through a post-transcriptional mechanism. dinactin also reduced pulmonary eosinophilia when administered within 1 d of airway antigen challenge [3].
Einzelnachweise
[1] laprade r, grenier f, pagé-dansereau m, et al. carrier-mediated ion transport in lipid bilayer membranes[j]. canadian journal of biochemistry and cell biology, 1984, 62(8): 738-751.
[2] silva l j, crevelin e j, souza w r, et al. streptomyces araujoniae produces a multiantibiotic complex with ionophoric properties to control botrytis cinerea[j]. phytopathology, 2014, 104(12): 1298-1305.
[3] umland s p, shah h, jakway j p, et al. effects of cyclosporin a and dinactin on t-cell proliferation, interleukin-5 production, and murine pulmonary inflammation[j]. american journal of respiratory cell and molecular biology, 1999, 20(3): 481-492.

NSC63925 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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