N(L-TYROSINE)-9Z,12Z,15Z-OCTADECATRIENAMIDE

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N(L-TYROSINE)-9Z,12Z,15Z-OCTADECATRIENAMIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Certain chronic neurologic disorders, such as Parkinson’s disease, are caused by an insufficiency of the neurotransmitter dopamine secondary to the degeneration of substantia nigra dopaminergic neurons.¹ N-(α-Linolenoyl) tyrosine (NALT) is a simple α-amide conjugate between the ω-3 essential fatty acid α-linolenate and the amino acid tyrosine. α-Linolenate is an important precursor to docosahexaenoic acid (DHA), a prominent brain polyunsaturated fatty acid, while tyrosine is the metabolic precursor for neuronal dopamine synthesis. NALT was prepared as a method for enhancing central nervous system (CNS) dopamine content by facilitated transport of the tyrosine precursor across the blood-brain barrier.² In experimental rat models of dopamine insufficiency, NALT increased CNS dopamine levels and exhibited an activity profile consistent with an anti-Parkinson’s therapeutic agent.²

• Definition

  ChEBI: N-(alpha-Linolenoyl) Tyrosine is a tyrosine derivative.

• Einzelnachweise

  1. Martin, J.B. Molecular basis of the neurodegenerative disorders N. Engl. J. Med. 340(25),1970-1980(1999).
  2. Yehuda, S. Possible anti-Parkinson properties of N-(α-linolenoyl) tyrosine: A new molecule Pharmacol. Biochem. Behav. 72(1-2),7-11(2002).

N(L-TYROSINE)-9Z,12Z,15Z-OCTADECATRIENAMIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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