Naltrexone hydrochloride

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

Naltrexone hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R22:Gesundheitsschädlich beim Verschlucken.

• S-Sätze Betriebsanweisung:

  S22:Staub nicht einatmen.
  S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

• Beschreibung

  Naltrexone hydrochloride is a potent, long-acting, orally-effective narcotic antagonist useful in the management of narcotic addiction.

• Chemische Eigenschaften

  White Crystalline Powder

• Originator

  Endo (USA)

• Verwenden

  Narcotic antagonist, In treatment of?alcoholism

• Verwenden

  sulfonamide, carbonic anhydrase inhibitor, anti-glaucoma agent

• Verwenden

  Nonselective opioid receptor antagonist; congener of naloxone

• Verwenden

  Naltrexone hydrochloride has been used:
  as an opioid antagonist, to analyse its effect on ethanol preference using Caenorhabditis elegans as a model.
  to determine its effectiveness in reducing the preference for substance of abuse (SOA) like nicotine and cocaine using Caenorhabditis elegans as a model.
  in the preparation of combinatorial drug, PXT3003 for treating Charcot-Marie-Tooth disease 1A (CMT1A) transgenic rat model Pmp22.

• Definition

  ChEBI: Naltrexone hydrochloride is a hydrochloride obtained by reaction of oxycodone with one molar equivalent of hydrochloric acid. it is a mu-opioid receptor antagonist that is used to treat alcohol dependence. It has a role as a mu-opioid receptor antagonist, an antidote to opioid poisoning and a central nervous system depressant. It contains a naltrexone(1+).

• Trademarks

  TREXAN

• Biologische Aktivität

  Opioid antagonist.

• Biochem/physiol Actions

  Competitive antagonist for μ, κ, δ, and σ-opioid receptors; has greater oral efficacy and longer duration of action than naloxone.

• Clinical Use

  Opioid antagonist:
  Adjunctive prophylactic treatment in patient’s previously opioid dependant
  Treatment of alcohol dependence

• Arzneimittelwechselwirkung

  Potentially hazardous interactions with other drugs
  Opioids: Avoid concomitant use.

• Stoffwechsel

  Naltrexone is well absorbed from the gastrointestinal tract but is subject to considerable first-pass metabolism and may undergo enterohepatic recycling. It is extensively metabolised in the liver and the major metabolite, 6-β-naltrexol, may also possess weak opioid antagonist activity. It is excreted mainly in the urine, <5% is excreted in the faeces. The renal clearance for naltrexone ranges from 30-127 mL/min and suggests that renal elimination is primarily by glomerular filtration

• Lager

  Room temperature

• läuterung methode

  This narcotic antagonist has been purified by recrystallisation from MeOH and dried in air. The free base has m 168-170o after recrystallisation from Me2CO. [Cone et al. J Pharm Sci 64 618 1975, Gold et al. Med Res Rev 2 211 1982.]

Naltrexone hydrochloride Upstream-Materialien And Downstream Produkte

Naltrexone hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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