5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz

Bezeichnung:5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz

CAS-Nr71-73-8

Englisch Name:Thiopental Sodium

CBNumberCB7106914

SummenformelC11H17N2NaO2S

Molgewicht264.32

MOL-Datei71-73-8.mol

Synonyma

Thiopentalnatrium

5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz

5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz physikalisch-chemischer Eigenschaften

Löslichkeit	H₂O: >10 mg/mL
Farbe	Yellowish hygroscopic powder
EPA chemische Informationen	Thiopental sodium (71-73-8)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	25
S-Sätze:	36-45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS-Nr.	CQ6475000
HazardClass	6.1(b)
PackingGroup	III
Toxizität	LD50 in mice (mg/kg): 149 i.p.; 78 i.v. (Christensen, Lee)

Gefahreninformationscode (GHS)

Thiopental Sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R25:Giftig beim Verschlucken.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
Beschreibung
Thiopental sodium , the sodium salt of 5-ethyl-5-(1-methylbutyl)thiobarbituric acid, a yellowish-white, crystalline, slightly bitter powder, is very soluble in water and soluble in alcohol. The compound is hygroscopic and has a weak unpleasant odor. The free acid forms colorless crystals, mp 158 – 159 ?C.A10%solution of the sodium salt has a pH of 10.6.
Chemische Eigenschaften
Yellowish-white, hygroscopic powder.
Verwenden
Pentothal (Abbott).
Definition
A rapidly acting barbiturate administered intravenously for general anesthesia and hypnosis. Commonly known as “truth serum.”
Trademarks
Thiopental is BAN.
Hazard
May cause respiratory failure; use onlywith physician in attendance.
Pharmakokinetik
Thiopental is highly bound to albumin, and free drug availability is increased in hypoproteinaemia. Protein binding is decreased by alkalaemia, hyperventilation and some drugs that occupy the same albumin binding sites, thereby increasing unbound thiopental concentrations. Metabolism occurs predominantly in the liver, and the metabolites are excreted by the kidneys. Only a small proportion is excreted unchanged in the urine. The terminal elimination half-life is approximately 11.5h (longer in the elderly). Elimination after an infusion is a zero-order process with 10%–15% of the remaining drug metabolised each hour. Up to 30% of the original dose may remain in the body at 24h, and a hangover effect is common. Accumulation may result if further doses of thiopental are administered within 1–2 days.
Clinical Use
Thiopental sodium is a short-acting intravenous anesthetic used for brief surgical procedures and induction of anesthesia. It is a potent,rapidly effective hypnotic. Sleep ensues within 30 – 60 s. A disadvantage is the lengthy hangover. In the United States and Great Britain it is the most widely used injection anesthetic. Abuse can lead to addiction.
Sicherheitsprofil
Poison by ingestion, intraperitoneal, rectal, subcutaneous, and intravenous routes. Human systemic effects by intraarterial route: acute arterial occlusion; by rectal route: respiratory depression, body temperature decrease, general anesthetic. An experimental teratogen. Experimental reproductive effects. An intravenous anesthetic. When heated to decomposition it emits toxic fumes of NO, and Na2O. See also PENTOTHAL and BARBITURATES
Veterinary Drugs and Treatments
Because of its rapid action and short duration, in young, healthy animals, thiopental is excellent induction agent (rapid IV bolus) for general anesthesia with other anesthetics or as the sole anesthetic agent for very short procedures. In sick or debilitated animals, thiopental may be used in a more cautious manner (IV, slowly to effect).

Thiopental Sodium Upstream-Materialien And Downstream Produkte

5-Ethyldihydro-5-(1-methylbutyl)-2-thioxo-4,6(1H,5H)-pyrimidindion,Mononatrium-Salz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

71-73-8, Thiopental Sodium Verwandte Suche:

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