Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)-

Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Chemische Eigenschaften,Einsatz,Produktion Methoden

• Biologische Aktivität

  21-Deoxycortisol-d8 is intended for use as an internal standard for the quantification of 21-deoxycortisol by GC- or LC-MS. 21-Deoxycortisol is a corticosteroid metabolite of 17-hydroxyprogesterone produced in the adrenal gland via 11-hydroxylation by 11β-hydroxylase.1,2 Serum levels of 21-deoxycortisol are elevated in patients with congenital adrenal hyperplasia that are heterozygous for mutations in CYP2A21, the gene encoding steroid 21-hydroxylase, and have been used as a biomarker for the detection of 21-hydroxylase deficiencies.

• Einzelnachweise

  1.Fiet, J., Villette, J.-M., Galons, H., et al.The application of a new highly-sensitive radioimmunoassay for plasma 21-deoxycortisol to the detection of steroid-21-hydroxylase deficiencyAnn. Clin. Biochem.31(Pt. 1)56-64(1994) 2.Cristoni, S., Cuccato, D., Sciannamblo, M., et al.Analysis of 21-deoxycortisol, a marker of congenital adrenal hyperplasia, in blood by atmospheric pressure chemical ionization and electrospray ionization using multiple reaction monitoringRapid Commun. Mass Spectrom.18(1)77-82(2004)

Pregn-4-ene-3,20-dione-2,2,4,6,6,21,21,21-d8, 11,17-dihydroxy-, (11β)- Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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