Pramipexole dihydrochloride monohydrate

Bezeichnung:Pramipexole dihydrochloride monohydrate

CAS-Nr191217-81-9

Englisch Name:Pramipexole dihydrochloride monohydrate

CBNumberCB6969615

SummenformelC10H20ClN3OS

Molgewicht265.8

MOL-Datei191217-81-9.mol

Pramipexole dihydrochloride monohydrate physikalisch-chemischer Eigenschaften

Schmelzpunkt	290 °C(dec.)
storage temp.	2-8°C
Löslichkeit	Freely soluble in water, soluble in methanol, sparingly soluble or slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
Aggregatzustand	Solid
Farbe	White to Almost white
Merck	14,7705
BCS Class	1
InChI	InChI=1/C10H17N3S.ClH.H2O/c1-2-5-12-7-3-4-8-9(6-7)14-10(11)13-8;;/h7,12H,2-6H2,1H3,(H2,11,13);1H;1H2/t7-;;/s3
InChIKey	ZTZQAWQFTIVKMU-DCFBZVEJNA-N
SMILES	NC1SC2C[C@@H](NCCC)CCC=2N=1.Cl.O \|&1:5,r\|

Sicherheit

WGK Germany	3
RTECS-Nr.	DL3375000
HS Code	2934200000

Gefahreninformationscode (GHS)

Pramipexole dihydrochloride monohydrate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Pramipexole dihydrochloride monohydrate is an activator of D2DR, D3DR and D4DR. Pramipexole has been found to have neuroprotective effects independent of its dopamine receptor agonism. It reduces mitochondrial reactive oxygen species (ROS) production and inhibits the activation of apoptotic pathways.
Chemische Eigenschaften
White or almost white, crystalline powder.
Verwenden
Pramipexole is a drug used to treat the symptoms of Parkinson's Disease (PD) and a antidepressant. It is a non-ergot dopamine agonist drug that is efficacious in treating various Parkinson's symptoms such as tremor, rigidity, and bradykinesia (slow movement)
Definition
ChEBI: A hydrate that is the monohydrate of the dihydrochloride salt of pramiprexole.
Trademarks
Mirapex (Boehringer Ingelheim).
Allgemeine Beschreibung
Pramipexole Dihydrochloride is a non-ergot dopamine agonist widely used for the treatment of early and advanced Parkinson′s disease (PD). It is also used to treat restless legs syndrome.
Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.
Clinical Use
Parkinson’s disease

Symptomatic treatment of restless legs
Nebenwirkungen
Dizziness, lightheadedness, or fainting, especially when standing up suddenly from a sitting/lying position.
drowsiness.
nausea.
seeing, hearing, or feeling things that are not there.
trouble sleeping.
twitching, twisting, or other unusual body movements.
unusual tiredness or weakness.
Arzneimittelwechselwirkung
Potentially hazardous interactions with other drugs
Avoid concomitant use with antipsychotics.
Stoffwechsel
Pramipexole undergoes <10% metabolism to inactive metabolites.
More than 90% of a dose is excreted via renal tubular secretion unchanged into the urine.

Pramipexole dihydrochloride monohydrate Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

191217-81-9, Pramipexole dihydrochloride monohydrate Verwandte Suche:

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