Iodoxaminsure

Bezeichnung:Iodoxaminsure

CAS-Nr31127-82-9

Englisch Name:iodoxamic acid

CBNumberCB6937203

SummenformelC26H26I6N2O10

Molgewicht1287.92

MOL-Datei31127-82-9.mol

Synonyma

Iodoxaminsure

Iodoxaminsure physikalisch-chemischer Eigenschaften

Siedepunkt	977.7±65.0 °C(Predicted)
Dichte	2.423±0.06 g/cm3(Predicted)
pka	pKa 1.8/2.8(H2O,t = 25) (Uncertain)

iodoxamic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Endobil,Bracco
Verwenden
Diagnostic aid (radiopaque medium).
Definition
ChEBI: Iodoxamic acid is an organic molecular entity.
Manufacturing Process
148.5 g 4,7,10,13-tetraoxahexadecane-1,16-dinitrile (U.S. Patent No. 2,401,607) was added to a solution of 232 g (2.45 mol) concentrate sulfuric acid in 290 ml absolute ethanol at 15°C. The mixture was heated at reflux for 15 hours, cooled and poured into 1000 g ice and 250 g ammonium sulfate. It was extracted with methylene chloride, dried and a solvent was removed in vacuum. The residue was distilled to give 4,7,10,13-tetraoxahexadecane-1,16- dicarbonic acid dimethyl ester; BP: 190°-195°C/0.005 mm Hg.
1 mol above prepared diester was saponificated with equivalent of NaOH in water. The reaction mixture was heated for 90 minutes. On cooling it was extracted with ether and the water layer was evaporated to dryness. The residue was washed with acetone. The obtained disodium salt of 4,7,10,13- tetraoxahexadecane-1,16-dicarbonic acid (yield 100%; MP: 102°-104°C) was acidified with calculated quantity of HCl to give the dicarbonic acid. The solvent was evaporated to dryness. Acetone was added to the residue for removing a by-product (sodium chloride) by filtration. Acetone was evaporated and the residue was extracted with ether, dried and evaporated. The residual liquid was 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid.
100 ml thionyl chloride was cautious added to 56 g above prepared diacid and heated at 40°-50°C and excess thionyl chloride was distilled in vacuum. The residue was the 4,7,10,13-tetraoxahexadecane-1,16-dicarbonic acid dichloride. The desired iodoxamic acid was prepared from above dichloride and 3-amino-2,4,6-trijode benzoic acid, in dimethylacetamide
Trademarks
Endobil (Bracco Industria Chimica S.p.A.,Italy); Endomirabil (Bracco Industria Chimica S.p.A., Italy); Videocolangio (Bracco Industria Chimica S.p.A., Italy).
Therapeutic Function
Diagnostic aid

iodoxamic acid Upstream-Materialien And Downstream Produkte

Iodoxaminsure Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

31127-82-9, iodoxamic acid Verwandte Suche:

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