8-Chinolylamin

Bezeichnung:8-Chinolylamin

CAS-Nr578-66-5

Englisch Name:8-Aminoquinoline

CBNumberCB6853868

SummenformelC9H8N2

Molgewicht144.17

MOL-Datei578-66-5.mol

Synonyma

8-Chinolylamin

8-Chinolylamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	60-65 °C (lit.)
Siedepunkt	174 °C/26 mmHg (lit.)
Dichte	1.1148 (estimate)
Brechungsindex	1.7080 (estimate)
Flammpunkt	174°C/26mm
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
Aggregatzustand	Crystalline Powder
pka	pK1: 3.99(+1) (20°C,μ=0.01)
Farbe	Green to beige-brown
Wasserlöslichkeit	slightly soluble
Sensitive	Air Sensitive
BRN	114474
CAS Datenbank	578-66-5(CAS DataBase Reference)
NIST chemische Informationen	8-Quinolinamine(578-66-5)
EPA chemische Informationen	8-Quinolinamine (578-66-5)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	68-36/37/38-20/21/22-36/38
S-Sätze:	36/37/39-26-22-36
RIDADR	UN2811
WGK Germany	3
RTECS-Nr.	VA9627000
Hazard Note	Harmful/Irritant/Air Sensitive
TSCA	Yes
HazardClass	IRRITANT
HS Code	29334990
Toxizität	mmo-sat 50 mg/plate MUREAV 39,285,77

Gefahreninformationscode (GHS)

8-Aminoquinoline Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R68:Irreversibler Schaden möglich.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/38:Reizt die Augen und die Haut.
S-Sätze Betriebsanweisung:
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
green to beige-brown crystalline powder
Verwenden
8-Aminoquinoline is used as pesticide and pharmaceutical intermediate. It has been used in the preparation of base-stabilized terminal borylene complex of osmium. It is also used in the spectrophotometric determination of bivalent palladium.
synthetische
Synthesis of 8-aminoquinoline: Under an ice bath, sulfuric acid (2.0 mL) was added onto quinoline (5 mmol, 1.0 equiv) then 65% nitric acid (3.0 equiv) were added dropwise and stirred for 4h at rt. The mixture was poured into the ice water and neutralized with NaOH; and then extracted with dichloromethane. After dried over Na2SO4 and evaporated in vacuo, used next step without purification.
Mixture of nitroquinolines and 5% Pd/C was solved in ethanol and suspension was saturated with hydrogen gas under atmospheric pressure at 40°C until the starting material was consumed. 2 h later, the mixture was filtered and evaporated. The crude product was purified by silica gel column chromatography, eluting with EtOAc in hexanes to yield the desired 8-aminoquinoline is isolated as a brown solid in a yield of 32%.
Obtained as a brown solid (231 mg, 32%); 1H NMR (500 MHz, CDCl3) δ 8.71 – 8.60 (m, 1H), 7.93 (d, J = 8.2 Hz, 1H), 7.29 – 7.16 (m, 2H), 7.02 (d, J = 8.1 Hz, 1H), 6.80 (d, J = 7.4 Hz, 1H), 4.89 (s, 2H).
Allgemeine Beschreibung
8-Aminoquinoline fluoresce moderately to weakly in low dielectric media but not in strongly hydrogen-bonding or acidic aqueous media. The reaction of 8-aminoquinoline with chromium (III), manganese (II), iron (II) and (III), cobalt (II), nickel (II), copper (II), zinc (II), cadmium (II) and platinum (II) salts has been studied.
Sicherheitsprofil
Human mutation data reported.When heated to decomposition it emits toxic fumes ofNOx.
läuterung methode
8-Aminoquinoline crystallises from EtOH, ligroin, octane or H2O, and complexes with metals. [Beilstein 22 III/IV 4708, 22/10 V 316.]

8-Aminoquinoline Upstream-Materialien And Downstream Produkte

8-Chinolylamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

578-66-5, 8-Aminoquinoline Verwandte Suche:

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