ALLOXAN MONOHYDRATE

Bezeichnung:ALLOXAN MONOHYDRATE

CAS-Nr2244-11-3

Englisch Name:ALLOXAN MONOHYDRATE

CBNumberCB6771957

SummenformelC4H4N2O5

Molgewicht160.09

MOL-Datei2244-11-3.mol

ALLOXAN MONOHYDRATE physikalisch-chemischer Eigenschaften

Schmelzpunkt	255 °C (dec.)(lit.)
storage temp.	2-8°C
Löslichkeit	H₂O: may be hazy yellow
Aggregatzustand	Crystalline Powder
Farbe	Off-white to beige-yellow
Wasserlöslichkeit	Soluble in water, ethanol, acetone, glacial acetic acid and methanol. Slightly soluble in chloroform, petroleum ether, toluene, ethyl acetate and acetic anhydride. Insoluble in ether.
Sensitive	Air Sensitive
Merck	14,282
BRN	5309394
CAS Datenbank	2244-11-3(CAS DataBase Reference)
EPA chemische Informationen	2,4,5,6(1H,3H)-Pyrimidinetetrone, monohydrate (2244-11-3)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	36-26-36/37
WGK Germany	3
RTECS-Nr.	UW0492000
TSCA	Yes
HS Code	29335995

Gefahreninformationscode (GHS)

ALLOXAN MONOHYDRATE Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Chemische Eigenschaften
Off-white to beige-yellowish crystalline powder
Verwenden
A cytotoxic compound, Alloxan Monohydrate causes oxidative base damage to nuclear DNA.
Verwenden
specific cytotoxin (beta pacreatic cell)
Verwenden
Cytotoxic compound that causes oxidative base damage to nuclear DNAAlloxan monohydrate is used as a precursor to prepare purple dye murexide. It is also used in research models to induce diabetes and destroy beta cells. Further, it is a strong oxidizing agent and it forms a hemiacetal with its reduced reaction product dialuric acid.
Sicherheitsprofil
Poison by intravenous route. An experimental teratogen. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits toxic fumes of NOx.
läuterung methode
Recrystallisation from H2O gave the tetrahydrate in large prisms or rhombs. On heating at 100o, or on exposure to air, this is converted to the monohydrate. Dissolve it in its own weight of boiling H2O and cool it for several days below 0o; the tetrahydrate crystallises from solution much more slowly when free from HNO3. It is less soluble in bicarbonate solutions than in H2O. Drying the solid over H2SO4 yields the monohydrate. The anhydrous crystals can be obtained by recrystallisation from dry Me2CO or AcOH followed by washing with dry Et2O, or by sublimation in a vacuum. On heating it turns pink at 230o and decomposes at ca 256o. It is acidic to litmus. [Hartman & Sheppard Org Synth Coll Vol III 37 1955.] It forms a compound with urea which crystallises from H2O in yellow needles that become red at 170o and decompose at 185-186o. [Beilstein 24 H 500, 24 I 428, 24 II 301, 24 III/IV 2137.]

ALLOXAN MONOHYDRATE Upstream-Materialien And Downstream Produkte

ALLOXAN MONOHYDRATE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2244-11-3, ALLOXAN MONOHYDRATE Verwandte Suche:

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