EPIDERMAL GROWTH FACTOR RECEPTOR

EPIDERMAL GROWTH FACTOR RECEPTOR Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  EGFR (HER1, ErbB1) is an RTK expressed on the surface of cells of mesodermal and ectodermal origin, and it mediates cell growth, proliferation, and differentiation in numerous organs [16, 17]. EGFR belongs to the ErbB family of RTKs, which also includes HER2 (ErbB2), HER3 (ErbB3), and HER4 (ErbB4). EGFR binds at least seven highly variable growth factor ligands [18]. Upon stimulation, EGFR undergoes combinatorial homo- or hetero-dimerization with one of the proteins of the HER family, thereby activating an expansive signaling network [16, 19, 20]. The EGFR transmembrane protein has a large extracellular component (with 4 domains, ~620 amino acids) that primarily serves as ligand-binding sites and which is anchored by a short helical transmembrane domain to the intracellular tyrosine kinase domain (TKD) (Fig.?1) [18].

• Mechanism of action

  EGFR is believed to play a role in the pathogenesis of lung cancer and is overexpressed in a majority of NSCLCs [21, 22]. However, the clinical importance of EGFR expression in the general NSCLC population is unclear. There was some suggestion that EGFR expression may serve as a predictive biomarker [21], but this has been superseded by mutational analysis after the identification of actionable driver mutations in the EGFR gene.

EPIDERMAL GROWTH FACTOR RECEPTOR Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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