1,8-Dihydroxy-3-(hydroxymethyl)anthrachinon

Bezeichnung:1,8-Dihydroxy-3-(hydroxymethyl)anthrachinon

CAS-Nr481-72-1

Englisch Name:Aloe emodin

CBNumberCB6727767

SummenformelC15H10O5

Molgewicht270.24

MOL-Datei481-72-1.mol

Synonyma

1,8-Dihydroxy-3-(hydroxymethyl)anthrachinon

1,8-Dihydroxy-3-(hydroxymethyl)anthrachinon physikalisch-chemischer Eigenschaften

Schmelzpunkt	223-224°C
Siedepunkt	373.35°C (rough estimate)
Dichte	1.3280 (rough estimate)
Brechungsindex	1.5000 (estimate)
storage temp.	2-8°C
Löslichkeit	Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
pka	6.30±0.20(Predicted)
Aggregatzustand	Solid
Farbe	Orange to Dark Orange
Merck	14,306
BRN	2059062
Stabilität	Hygroscopic
InChIKey	YDQWDHRMZQUTBA-UHFFFAOYSA-N
LogP	3.254 (est)
CAS Datenbank	481-72-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36
WGK Germany	3
RTECS-Nr.	CB6712200
F	10
HS Code	29146990

Gefahreninformationscode (GHS)

Aloe emodin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Orange Solid
Verwenden
Aloe-emodin has been used as a standard in high performance liquid chromatography (HPLC) for separation and identification of phenolic compounds in Aloe arborescens Miller var. natalensis Berger (Kidachi aloe).
Verwenden
Aloe-emodin may be used as an analytical reference standard for the determination of the analyte in plant and animal samples by high-performance liquid chromatography technique.
Verwenden
Shows significant inhibitory activity against the P-388 leukemia in mice when administered as a suspension in acetone-Tween 80. Has a specific in vitro and in vivo antineuroectodermal tumor activity. Cathartic.
Definition
ChEBI: A dihydroxyanthraquinone that is chrysazin carrying a hydroxymethyl group at position 3. It has been isolated from plant species of the genus Aloe.
Allgemeine Beschreibung
Diacerein is known to be a suitable drug to treat osteoarthritis and prevent vascular diseases. It is a semi-synthetic anthraquinone derivative which acts by inhibiting the production of interleukin-1 and secretion of metalloproteases.
Biochem/physiol Actions
Laxative/cathartic compound; increases the contraction of intestinal smooth muscle by releasing endogenous acetylcholine. Anti-tumor activity is associated with an increased production of reactive oxygen species (ROS) that, in turn, reduces the mitochondrial transmembrane electrical potential, thus inducing a permeability transition that sets in motion a series of events culminating in cellular apoptosis. Genotoxicity and mutagenicity appear to be due to the inhibition of topoisomerase II activity by aloe emodin.

Aloe emodin Upstream-Materialien And Downstream Produkte

1,8-Dihydroxy-3-(hydroxymethyl)anthrachinon Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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