HISPIDULIN

Bezeichnung:HISPIDULIN

CAS-Nr1447-88-7

Englisch Name:HISPIDULIN

CBNumberCB6723941

SummenformelC16H12O6

Molgewicht300.26

MOL-Datei1447-88-7.mol

HISPIDULIN physikalisch-chemischer Eigenschaften

Schmelzpunkt	291-292 °C
Siedepunkt	601.5±55.0 °C(Predicted)
Dichte	1.512±0.06 g/cm3(Predicted)
storage temp.	-20°C
Löslichkeit	DMSO: soluble20mg/mL, clear
Aggregatzustand	powder
pka	6.51±0.40(Predicted)
Farbe	white to beige

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
WGK Germany	3
RTECS-Nr.	DJ2996000

Gefahreninformationscode (GHS)

HISPIDULIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Hispidulin has been used as a calibration standard:
- in high-performance liquid chromatography (HPLC) for quantification of Clerodendrum petasites flavonoids
- in liquid chromatography/electrospray ionization mass spectrometry (LC/ESI-MS) analysis
- in reverse-phase high-performance liquid chromatography with a diode-array detector (HPLC-DAD) and high-performance thin-layer chromatography (HPTLC)
Definition
ChEBI: A monomethoxyflavone that is scutellarein methylated at position 6.
Allgemeine Beschreibung
This substance is a primary reference substance with assigned absolute purity (considering chromatographic purity, water, residual solvents, inorganic impurities). The exact value can be found on the certificate. Produced by PhytoLab GmbH & Co. KG
Biologische Aktivität
Partial positive allosteric modulator at the benzodiazepine receptor (IC 50 = 1.3 μ M for inhibition of flumazenil binding); natural sage flavone. Stimulates GABA-induced chloride currents in Xenopus oocytes expressing α 1 α 2-, α 3-, α 5- or α 6- β 2 γ 2S GABA A receptors. Brain penetrant; oral administration reduces seizures in a gerbil model of epilepsy. Also has antifungal, antiproliferative, antioxidant and antithrombotic properties.
Biochem/physiol Actions
Hispidulin is a bioactive flavonoid with a variety of effects including antiproliferative, antifungal, anti-inflammatory, antioxidative and antiepileptic activity. Like EGCG, hispidulin appears to activate AMPK and inhibit the PI3K/Akt/mTOR pathway. The antiepileptic activity may be due to additional activity as a benzodiazepine (BZD) receptor ligand.

HISPIDULIN Upstream-Materialien And Downstream Produkte

HISPIDULIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1447-88-7, HISPIDULIN Verwandte Suche:

Send Inquriy