2-Deoxy-L-ribose

Bezeichnung:2-Deoxy-L-ribose

CAS-Nr18546-37-7

Englisch Name:2-Deoxy-L-ribose

CBNumberCB6704755

SummenformelC5H10O4

Molgewicht134.13

MOL-Datei18546-37-7.mol

2-Deoxy-L-ribose physikalisch-chemischer Eigenschaften

Schmelzpunkt	69-72°C
alpha	57 º (c=0.9 H2O after 24h)
Siedepunkt	167.23°C (rough estimate)
Dichte	1.0590 (rough estimate)
Brechungsindex	1.4050 (estimate)
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	Methanol (Slightly), Water (Slightly)
pka	13.58±0.20(Predicted)
Aggregatzustand	Solid
Farbe	Light Yellow to Pale Beige
Optische Aktivität	[α]/D 54.0±2.0°, 24 hr, c = 1 in H2O
CAS Datenbank	18546-37-7(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xn,Xi
R-Sätze:	20/21/22-36/37/38
S-Sätze:	24/25-37/39-36-26
HS Code	29329990

Gefahreninformationscode (GHS)

2-Deoxy-L-ribose Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
Chemische Eigenschaften
white to light beige crystalline powder
Verwenden
2-Deoxy-L-ribose is an isomer of 2-Deoxy-D-ribose (D252000) which induces apoptosis by inhibiting the synthesis and increasing the efflux of glutathione.
Definition
ChEBI: 2-deoxy-L-arabinose is a deoxypentose. It is functionally related to a L-arabinose.
Vorbereitung Methode
The provides the synthetic process of 2-Deoxy-L-ribose comprising the steps of; (A) protection step in which aldehyde group of 2-deoxy-D-ribose is protected in the form of acetal. 2-deoxy-l-O-alkyl-D-ribopyranoside is prepared by the reaction of 2-deoxy-D-ribose with alcohol in the presence of acid; (B) activation step in which 3 -and 4-OH groups of 2-deoxy-D-ribose are activated. 2-deoxy-l-O-alkyl- 3,4-di-(alkanesulfonyl)-D-ribose or 2-deoxy-1-O-alkyl-3,4-di-(arylsulfonyl)-D-ribose is prepared by reaction of the above 2-deoxy-l-O-alkyl-D-ribose with organic sulfonylhalide for activation of 3- and 4-OH; (C) inversion step in which stereochemistry of 3- and 4-OH groups is changed. Reaction of the above 2-deoxy-l- O-alkyl-3,4-di-(alkanesulfonyl)-D-ribose or 2-deoxy-l-O-alkyl-3,4-di-(arylsulfonyl)- D-ribose with a metal salt of organic acid leads to 2-deoxy-L-ribose derivatives of which stereochemistry of 3- and 4-OH is different from the corresponding 2-deoxy-D- ribose derivatives; (D) deprotection step in which 2-deoxy-L-ribose is prepared by consecutive reactions of the step (C) products with acid and base.
läuterung methode
Crystallise 2-deoxy--L-ribose from diethyl ether. It can also be purified by dissolving the ribose (7.3g) in EtOAc (3L) by reflux, decanting from any insoluble mate

2-Deoxy-L-ribose Upstream-Materialien And Downstream Produkte

2-Deoxy-L-ribose Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

18546-37-7, 2-Deoxy-L-ribose Verwandte Suche:

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