Dynorphin A (1-13)

Dynorphin A (1-13) Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Dynorphin A(1-13), a tridecapeptide of the endogenous opioid peptides, has modest effects in reducing mild opiate withdrawal in humans. Previous studies revealed that dynorphin also potentiates the analgesic effect of morphine in morphine-tolerant rats and mice. The therapeutic potential of dynorphin A(1-13) is limited due to extensive metabolism by human metabolic enzymes resulting in an in vivo half-life of less than one minute. Chemical modifications of dynorphin A(1-13), such as N-methylation of Tyr1 and amidation of the C-terminus have been shown to be effective in protecting against the proteolytic enzymes in human plasma^[1].

• Application

  Dynorphin A (1-13) has been used as a test compound in the field asymmetric waveform ion mobility spectrometry coupled to mass spectrometry (FAIMS/IMS/MS).

• Biochem/physiol Actions

  Dynorphin A (1-13), a bioactive product of dynorphin A displays interaction with N-methyl- D-aspartate (NMDA) as well as with opioid receptors. It elevates intracellular calcium [Ca²⁺]i level and contributes to the loss of neurons affecting neuronal viability.

• Einzelnachweise

  [1] B BRUGOS; G H. Metabolism of dynorphin A(1-13).[J]. Pharmazie, 2004.

Dynorphin A (1-13) Upstream-Materialien And Downstream Produkte

Dynorphin A (1-13) Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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