N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid

Bezeichnung:N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid

CAS-Nr366-70-1

Englisch Name:Procarbazine hydrochloride

CBNumberCB6678902

SummenformelC12H20ClN3O

Molgewicht257.76

MOL-Datei366-70-1.mol

Synonyma

Procarbazinhydrochlorid

N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid

N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	223°C
Dichte	8.3 g/cm3
storage temp.	Inert atmosphere,2-8°C
Löslichkeit	DMSO: ≥18mg/mL
Aggregatzustand	powder
Farbe	white to tan
Wasserlöslichkeit	>=10 g/100 mL at 21.5 ºC
Merck	14,7758
BCS Class	3/1
CAS Datenbank	366-70-1(CAS DataBase Reference)
IARC	2A (Vol. 26, Sup 7) 1987
EPA chemische Informationen	Procarbazine hydrochloride (366-70-1)

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	45-61-22-68
S-Sätze:	53-36/37-45
WGK Germany	3
RTECS-Nr.	XS4725000
HS Code	2928002500
Toxizität	LD50 orally in rats: 785 ±34 mg/kg (Goldenthal)

Gefahreninformationscode (GHS)

Procarbazine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Crystalline Solid
Chemische Eigenschaften
Procarbazine is a white to pale yellow crystal- line powder with a slight odor.
Verwenden
Antineoplastic.
Verwenden
Antineoplastic;DNA replication inhibitor
Verwenden
Procarbazine hydrochloride USP is used to traet Hodgkin’s disease; non-Hodgkin’s lymphomas; lung cancer.
Definition
ChEBI: A hydrochloride obtained by combining procarbazine with one equivalent of hydrochloric acid. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaki g of DNA strands.
Trademarks
Matulane (Sigma-Tau).
Allgemeine Beschreibung
Procarbazine is available in 50-mg tablets for oral administrationin the treatment of Hodgkin’s (part of MOPP) andnon-Hodgkin’s disease, brain cancer, and mycosis fungoides.The major mechanisms of resistance appear to beenhanced activity of DNA-repair enzymes including enhancedO-6-alkylguanine DNA transferase (AGAT),which removes the methyl group from the O-6 of guanine.The agent is rapidly and completely absorbed after oral administrationand extensively metabolized in the liver togive azo-procarbazine followed by further oxidation tomethyldiazine and the aldehyde. The parent drug andmetabolites cross the blood-brain barrier. Elimination occursin the urine mostly as metabolites with an eliminationhalf-life of 1 hour. Myelosuppression is dose limiting, generallypresenting as thrombocytopenia that may be followedby leucopenia. Glucose-6-phosphate dehydrogenasedeficient patients may develop hemolytic anemia duringprocarbazine therapy. Other adverse effects include nausea,vomiting, hypersensitivity, flulike symptoms, amenorrhea,and azoospermia. Central nervous symptom effectsmay be seen, including lethargy, confusion, neuropathies,and seizure.
Allgemeine Beschreibung
White to pale yellow crystalline powder with a slight odor. Acid to litmus.
Air & Water Reaktionen
In the presence of moisture or in aqueous solution undergoes oxidation by atmospheric oxygen. Water soluble.
Reaktivität anzeigen
Procarbazine hydrochloride is very sensitive to light. Stability is highest in aqueous acid and decreases with increasing pH. Degrades rapidly in alcoholic media and more slowly in aqueous media .
Brandgefahr
Flash point data for Procarbazine hydrochloride are not available; however, Procarbazine hydrochloride is probably combustible.
Biologische Aktivität
Procarbazine is an antineoplastic alkylating agent widely used in cancer chemotherapy in combination with other compounds. It has multiple mechanisms of action. Procarbazine inhibits protein, RNA and DNA synthesis in addition to being an alkylating agent.', 'Procarbazine is metabolized to azoprocarbazine either by cytochrome P450 enzyme and monoamine oxidase in an NADPH (nicotinamide adenine diphosphate) dependent or independent manner. It is considered neurotoxic. Procarbazine is used in combination with therapy for treating Hodgkinμs disease.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Poison by an unspecified route. Moderately toxic by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Mutation data reported. When heated to decomposition it emits very toxic fumes of NOx and HCl. Used as a chemotherapeutic agent.
mögliche Exposition
Procarbazine is available in capsule form. The primary use of this drug is as an antineoplastic agent in the treatment of advanced Hodgkin’s disease, and oat-cell carcinoma of the lung. The hydrochloride com- pound is used in treatment. The FDA approved use of pro- carbazine hydrochloride in 1969 and indicated that the drug should be used as an adjunct to standard therapy. Possible exposure occurs during manufacture of the drug and direct exposure during its subsequent administration to patients. Some of the metabolites of procarbazine hydrochloride are both carcinostatic and carcinogenic.
Veterinary Drugs and Treatments
In veterinary medicine, procarbazine is used as part of MOPP protocols (mechlorethamine, vincristine, procarbazine, prednisone) to treat lymphomas in dogs and cats. It may be of benefit in treating granulomatous meningoencephalitis (GME) in dogs.
Versand/Shipping
UN2811 Toxic solids, organic, n.o.s., Hazard Class: 6.1; Labels: 6.1-Poisonous materials, Technical Name Required.
Inkompatibilitäten
Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides.
Waste disposal
It is inappropriate and possibly dangerous to the environment to dispose of expired or waste drugs and pharmaceuticals by flushing them down the toilet or discarding them to the trash. Household quantities of expired or waste pharmaceuticals may be mixed with wet cat litter or coffee grounds, double-bagged in plastic, discard in trash. Larger quanti- ties shall carefully take into consideration applicable DEA, EPA, and FDA regulations. If possible return the pharmaceutical to the manufacturer for proper disposal being careful to properly label and securely package the material. Alternatively, the waste pharmaceutical shall be labeled, securely packaged and transported by a state licensed medical waste contractor to dispose by burial in a licensed hazardous or toxic waste landfill or incinerator.

Procarbazine hydrochloride Upstream-Materialien And Downstream Produkte

N-(1-Methylethyl)-4-((2-methyl-hydrazino)methyl)benzamid-monohydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

366-70-1, Procarbazine hydrochloride Verwandte Suche:

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