10-((1-Methyl-3-pyrrolidinyl)-methyl)-10H-phenothiazin

Bezeichnung:10-((1-Methyl-3-pyrrolidinyl)-methyl)-10H-phenothiazin

CAS-Nr1982-37-2

Englisch Name:METHDILAZINE (200 MG)

CBNumberCB6501372

SummenformelC18H20N2S

Molgewicht296.43

MOL-Datei1982-37-2.mol

Synonyma

Methdilazin

10-((1-Methyl-3-pyrrolidinyl)-methyl)-10H-phenothiazin

10-((1-Methyl-3-pyrrolidinyl)-methyl)-10H-phenothiazin physikalisch-chemischer Eigenschaften

Schmelzpunkt	87-88℃
Siedepunkt	170 °C(Press: 0.04 Torr)
Dichte	1.185
Brechungsindex	1.6000 (estimate)
pka	pKa 7.45 (Uncertain)
EPA chemische Informationen	Methdilazine (1982-37-2)

METHDILAZINE (200 MG) Chemische Eigenschaften,Einsatz,Produktion Methoden

Originator
Tacaryl ,Westwood,US,1960
Verwenden
Antipruritic.
Definition
ChEBI: Methdilazine is a phenothiazine substituted on nitrogen by a (1-methylpyrrolidin-3-yl)methyl group; a first-generation antihistamine with anticholinergic properties. It has a role as a histamine antagonist, a cholinergic antagonist and an antipruritic drug. It is a member of phenothiazines and a N-alkylpyrrolidine.
Manufacturing Process
10.8 parts of 10-(1-methyl-3-pyrrolidylmethyl) phenothiazine (prepared from 1-methyl-3-pyrrolidylmethyl chloride by reaction with phenothiazine) in 80 parts of 99% isopropyl alcohol were treated with a solution of 1.33 parts of hydrogen chloride in 30 parts of the same solvent. The clear light yellow solution soon deposited white crystals of the acid addition salt. After cooling overnight at 0°C, the crystalline product was collected on a filter, washed with 99% isopropyl alcohol and anhydrous ether and then dried in a vacuum oven at 95°C. Yield 10.4 parts, MP 187.5° to 189°C.
Trademarks
Tacaryl (Westwood-Squibb).
Therapeutic Function
Antipruritic
Allgemeine Beschreibung
Methdilazine, 10-[(1-methyl-3-pyrrolidinyl)methyl]phenothiazine (Tacaryl), is a light-tan crystallinepowder that has a characteristic odor and is practicallyinsoluble in water. Methdilazine, as the free base, isused in chewable tablets because its low solubility in watercontributes to its tastelessness. Some local anesthesia of thebuccal mucosa may be experienced if the tablet is chewedand not swallowed promptly.
Allgemeine Beschreibung
Crystals.
Reaktivität anzeigen
METHDILAZINE (200 MG) is sensitive to light. .
Health Hazard
SYMPTOMS: Symptoms of exposure to METHDILAZINE (200 MG) may include drowsiness, hypotension, tachycardia, dryness of the mouth, nausea, nasal congestion, fever and tremors.
Brandgefahr
Flash point data for METHDILAZINE (200 MG) are not available. METHDILAZINE (200 MG) is probably combustible.

METHDILAZINE (200 MG) Upstream-Materialien And Downstream Produkte

10-((1-Methyl-3-pyrrolidinyl)-methyl)-10H-phenothiazin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

1982-37-2, METHDILAZINE (200 MG) Verwandte Suche:

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