Cyclizine Hydrochloride Struktur

Cyclizinhydrochlorid

Bezeichnung:Cyclizinhydrochlorid

CAS-Nr303-25-3

Englisch Name:Cyclizine Hydrochloride

CBNumberCB6500522

SummenformelC18H23ClN2

Molgewicht302.84162

MOL-Datei303-25-3.mol

Synonyma

Cyclizinhydrochlorid

Cyclizinhydrochlorid physikalisch-chemischer Eigenschaften

Schmelzpunkt	258-260℃
Siedepunkt	457.04°C (rough estimate)
Dichte	1.0551 (rough estimate)
Brechungsindex	1.5749 (estimate)
storage temp.	Refrigerator
Löslichkeit	Methanol: 1 mg/ml

Sicherheit

Kennzeichnung gefährlicher	T
R-Sätze:	61-23/24/25-42/43
S-Sätze:	53-22-36/37/39-45
RIDADR	3249
WGK Germany	3
HazardClass	6.1(b)
PackingGroup	III
HS Code	2933595960
Toxizität	mouse,LD50,intraperitoneal,58mg/kg (58mg/kg),Pharmacology: International Journal of Experimental and Clinical Pharmacology. Vol. 13, Pg. 241, 1975.

Gefahreninformationscode (GHS)

Cyclizine Hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Off-White Solid
moderately soluble in water
Originator
Marezine,BurroughsWellcome,US,1953
Verwenden
Motion sickness (prophylaxis and treatment)—Oral cyclizine is indicated for the prophylaxis and treatment of nausea, vomiting, and dizziness associated with motion sickness. Nausea and vomiting, postoperative (prophylaxis and treatment)—to prevent or reli
Verwenden
Cyclizine Hydrochloride is a piperazine derivative with anti-emetic activity that is useful in the prevention and treatment of nausea and vomiting associated with motion sickness. Antiemetic.
Definition
ChEBI: Cyclizine hydrochloride is a hydrochloride salt consisting of equimolar amounts of cyclizine and hydrogen chloride. It has a role as a H1-receptor antagonist, a central nervous system depressant, a cholinergic antagonist and an antiemetic. It contains a cyclizine.
Manufacturing Process
One-tenth mol (20 g) of benzhydryl chloride was mixed with 0.19 mol (19 g) of N-methylpiperazine and about 10 cc of benzene and the whole was heated on the steam bath four hours. The contents of the flask was partitioned between ether and water, and the ethereal layer was washed with water until the washings were neutral. The base was then extracted from the ethereal layer by N hydrochloric acid and the extract, made acid to Congo red paper, was evaporated under vacuum. 29.5 g of the pure dihydrochloride of Nmethyl-N'-benzhydryl piperazine was recovered from the residue by recrystallization from 95% alcohol melting above 250°C with decomposition. The addition of alkali to an aqueous solution of the dihydrochloride liberated the base which was recovered by recrystallization from petroleum ether melting at 105.5° to 107.5°C.
Therapeutic Function
Antinauseant

Cyclizine Hydrochloride Upstream-Materialien And Downstream Produkte

Cyclizinhydrochlorid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

303-25-3, Cyclizine Hydrochloride Verwandte Suche:

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