5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Struktur

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

Bezeichnung:5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

CAS-Nr148892-91-5

Englisch Name:5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM

CBNumberCB6497387

SummenformelC10H18N6NaO13P3

Molgewicht546.19

MOL-Datei148892-91-5.mol

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM physikalisch-chemischer Eigenschaften

storage temp.	-70°C
Löslichkeit	H₂O: 50 mg/mL
Aggregatzustand	powder
Farbe	white

Sicherheit

Kennzeichnung gefährlicher	Xi
R-Sätze:	36/37/38
S-Sätze:	26-36/37
WGK Germany	3
F	10-21

Gefahreninformationscode (GHS)

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
Verwenden
Guanosine 5′-[β,γ-imido]triphosphate trisodium salt hydrate has been used: to study K-RAS interactions with the membrane, for the crystallization of Mycobacterium tuberculosis FtsZ, as a translation initiation inhibitor for the analysis of the 48S pre-initiation complex.
Verwenden
Non-hydrolyzable analog of GTP; the preferred GTP analog to activate ADP-ribosylation factor.
Allgemeine Beschreibung
Guanosine 5′-[β,γ-imido]triphosphate (GMP-PNP, Gpp(NH)p) is a non-hydrolyzable analog of GTP that binds and irreversibly activates G proteins. Gpp(NH)p is used in a variety of applications that involve GTP binding, including GTP-activation, GTP-inhibition, GTP transport, GTP hydrolysis, and GTP structure stabilization. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, guanosine 5′-[β,γ-imido]triphosphate is often used in studies of protein synthesis. Gpp(NH)p is used to activate ADP-ribosylation factors and to modulate G proteins involved in cell signaling, protein synthesis and other metabolic processes.
Biochem/physiol Actions
Guanosine 5′-[?,γ-imido]triphosphate binds and irreversibly activates G proteins. Since a cycle of GTP binding, hydrolysis, and release is required for the initiation of protein translocation across the endoplasmic reticulum, this non-hydrolyzable GTP analog is often used in studies of protein synthesis.

5'-GUANYLYLIMIDODIPHOSPHATE TRISODIUM Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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