N-(4-Nitrophenyl)-L-glutamin

Bezeichnung:N-(4-Nitrophenyl)-L-glutamin

CAS-Nr7300-59-6

Englisch Name:L-Glutamic acid γ-(4-nitroanilide)

CBNumberCB6496764

SummenformelC11H13N3O5

Molgewicht267.24

MOL-Datei7300-59-6.mol

Synonyma

N-(4-Nitrophenyl)-L-glutamin

N-(4-Nitrophenyl)-L-glutamin physikalisch-chemischer Eigenschaften

Schmelzpunkt	185-188°C
alpha	[α]D20 +36～+39°(c=2,dil.HCl)
Siedepunkt	590.6±50.0 °C(Predicted)
Dichte	1.463
Brechungsindex	32 ° (C=2, 0.5mol/L HCl)
storage temp.	2-8°C
Löslichkeit	Aqueous Acid (Slightly)
pka	2.21±0.10(Predicted)
Aggregatzustand	Solid
Farbe	White to Pale Yellow
BRN	2818758
InChI	InChI=1S/C11H13N3O5/c12-10(15)6-5-9(11(16)17)13-7-1-3-8(4-2-7)14(18)19/h1-4,9,13H,5-6H2,(H2,12,15)(H,16,17)/t9-/m0/s1
InChIKey	IMTMBDXEKMXETQ-VIFPVBQESA-N
SMILES	C(O)(=O)[C@H](CCC(N)=O)NC1=CC=C([N+]([O-])=O)C=C1
CAS Datenbank	7300-59-6(CAS DataBase Reference)
EPA chemische Informationen	L-Glutamine, N-(4-nitrophenyl)- (7300-59-6)

Sicherheit

S-Sätze:	22-24/25
WGK Germany	3
TSCA	TSCA listed
HS Code	29242990
Speicherklasse	11 - Combustible Solids

Gefahreninformationscode (GHS)

L-Glutamic acid γ-(4-nitroanilide) Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Beschreibung
L-Glutamic acid γ-(4-nitroanilide) is a substrate for γ-glutamyltransferase (GGT). It is an important enzyme that is widely used in biocatalysis and clinical diagnostics.
Chemische Eigenschaften
cream coloured to light yellow powder
Verwenden
Substrate for gamma-glutamyl transpeptidase
synthetische
To a microwave vial containing a solution of Boc-L-glutamic acid tert-butyl ester (0.165 mmol, 1.0 equiv) and HATU (0.165 mmol, 1.0 equiv) in DMF (1.65 mL) was added the amine followed by DIPEA (57.5 μL, 2.0 equiv). The vial was sealed and heated under microwave irradiation for 30 min at 120 °C. Upon completion, the reaction was partitioned between water and CH2Cl2, extracted 3× with CH2Cl2, dried over anhydrous Na2SO4, and concentrated under vacuum. Compounds were purified via reverse phase chromatography (5-95% acetonitrile/water) to afford the N-Boc-glutamylanilide-tert-butyl esters. The compounds were transferred to vials followed by the addition of 2.0 mL of 4.0 M HCl in dioxane. The reaction stirred at 40 °C for 4 h. The reactions were concentrated under vacuum to afford L-Glutamic acid γ-(4-nitroanilide).
Solubility in water
Soluble in water, formic acid (50 mg/ml), and 0.5mol/l hydrochloric acid. Chloroform: Slightly soluble. DMF: Slightly soluble. DMSO: Slightly soluble. Ethanol: Slightly soluble. Methanol: Slightly soluble. PBS (pH 7.2): Slightly soluble

L-Glutamic acid γ-(4-nitroanilide) Upstream-Materialien And Downstream Produkte

N-(4-Nitrophenyl)-L-glutamin Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

7300-59-6, L-Glutamic acid γ-(4-nitroanilide) Verwandte Suche:

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