1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz

Bezeichnung:1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz

CAS-Nr128-44-9

Englisch Name:Saccharin sodium

CBNumberCB6485865

SummenformelC7H5NNaO3S

Molgewicht206.17

MOL-Datei128-44-9.mol

Synonyma

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300°C
Dichte	1.69[at 20℃]
Dampfdruck	0Pa at 25℃
FEMA	2997 \| SACCHARINE, SODIUM SALT
storage temp.	0-6°C
Löslichkeit	H2O: 1 M at 20 °C, clear, colorless; sparingly soluble in ethanol.
pka	0.003-0.003[at 20 ℃]
Farbe	White crystals or a white, crystalline efflorescent powder
Geruch (Odor)	odourless or with a faint, aromatic odour
Wasserlöslichkeit	>=10 g/100 mL at 20 ºC
Stabilität	Stable. Incompatible with strong oxidizing agents.
InChIKey	WINXNKPZLFISPD-UHFFFAOYSA-M
LogP	-2.84-0.11 at 25℃
CAS Datenbank	128-44-9(CAS DataBase Reference)
EPA chemische Informationen	Saccharin sodium (128-44-9)

Sicherheit

S-Sätze:	24/25
WGK Germany	2
RTECS-Nr.	DE4550000
Toxizität	LD50 oral in rat: 14200mg/kg

Gefahreninformationscode (GHS)

Saccharin sodium Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
Saccharin sodium occurs as a white, odorless or faintly aromatic, efflorescent, crystalline powder. It has an intensely sweet taste, with a metallic or bitter aftertaste that at normal levels of use can be detected by approximately 25% of the population. The aftertaste can be masked by blending saccharin sodium with other sweeteners. Saccharin sodium can contain variable amounts of water.
Verwenden
Saccharin Sodium is a flavoring agent and non-nutritive sweetener. It is a salt of saccharin widely used as sweetener in food and beverage. As a high-intensity sweetener, Saccharin Sodium can be used in a wide variety of industries including: food production, beverage, cosmetics, agriculture/animal feed, and various other industries. Saccharin Sodium Salt Hydrate can be used for the purification of recombinant polypeptides, such as antibodies.
Definition
ChEBI: Saccharin sodium is an organic molecular entity.
Vorbereitung Methode
Saccharin is produced by the oxidation of o-toluene sulfonamide by potassium permanganate in a solution of sodium hydroxide. Acidification of the solution precipitates saccharin, which is then dissolved in water at 50℃ and neutralized by addition of sodium hydroxide. Rapid cooling of the solution initiates crystallization of saccharin sodium from the liquors.
Trademarks
Sucaryl (Ross).
Allgemeine Beschreibung
Saccharin sodium appears as odorless white crystals or crystalline powder. Aqueous solution is neutral or alkaline to litmus, but not alkaline to phenolphthalein. Effloresces in dry air. Intensely sweet taste. (NTP, 1992)
Air & Water Reaktionen
Water soluble.
Reaktivität anzeigen
Saccharin sodium may react with oxidizing agents. . Very weak base in aqueous solution.
Hazard
The use of saccharin is being limited due to possible carcinogenicity.
Brandgefahr
Flash point data are not available for Saccharin sodium , but Saccharin sodium is probably combustible.
Pharmazeutische Anwendungen
Saccharin sodium is an intense sweetening agent used in beverages, food products, table-top sweeteners, and pharmaceutical formulations such as tablets, powders, medicated confectionery, gels, suspensions, liquids, and mouthwashes. It is also used in vitamin preparations.
Saccharin sodium is considerably more soluble in water than saccharin, and is more frequently used in pharmaceutical formulations. Its sweetening power is approximately 300–600 times that of sucrose. Saccharin sodium enhances flavor systems and may be used to mask some unpleasant taste characteristics.
Injection of saccharin sodium has been used to measure the armto- tongue circulation time.
Sicherheitsprofil
Confirmed carcinogen with experimental carcinogenic, neoplastigenic, tumorigenic, and teratogenic data. Moderately toxic by ingestion and intraperitoneal routes. A promoter. Experimental reproductive effects. Human mutation data reported. When heated to decomposition it emits very toxic fumes of SOx, Na2O, and NOx.
Sicherheit(Safety)
There has been considerable controversy concerning the safety of saccharin and saccharin sodium in recent years; however, it is now generally regarded as a safe, intense sweetener. See Saccharin for further information.
The WHO has set a temporary acceptable daily intake of up to 2.5 mg/kg body-weight for saccharin, including its salts.(3) In the UK, the Committee on Toxicity of Chemicals in Food, Consumer Products, and the Environment (COT) has set an acceptable daily intake for saccharin and its salts (expressed as saccharin sodium) at up to 5 mg/kg body-weight.
LD50 (mouse, oral): 17.5 g/kg
LD50 (rat, IP): 7.1 g/kg
LD50 (rat, oral): 14.2 g/kg
mögliche Exposition
The information provided has to do, primarily, with the manufacturing of saccharin. Saccharin has been used as a nonnutritive sweetening agent. At one point the United States consumption pattern for all forms of saccharin has been estimated as 45% in soft drinks; 18% in tabletop sweeteners; 14% in fruits, juices, sweets, chew- ing gum, and jellies; 10% in cosmetics and oral hygiene products; 7% in drugs, such as coating on pills; 2% in tobacco; 2% in electroplating; and 2% for miscellaneous uses. Human exposure to saccharin occurs primarily through ingestion because of its use in many dietic foods and drinks and some personal hygiene products, including toothpastes and mouthwashes. The general public is exposed to saccharin, especially by persons required to reduce sugar intake.
Lager
Saccharin sodium is stable under the normal range of conditions employed in formulations. Only when it is exposed to a high temperature (125℃) at a low pH (pH 2) for over 1 hour does significant decomposition occur. The 84% grade is the most stable form of saccharin sodium since the 76% form will dry further under ambient conditions. Solutions for injection can be sterilized by autoclave.
Saccharin sodium should be stored in a well-closed container in a dry place.
Versand/Shipping
UN3077 Environmentally hazardous substances, solid, n.o.s., Hazard class: 9; Labels: 9-Miscellaneous haz- ardous material, Technical Name Required.
Inkompatibilitäten
Saccharin sodium does not undergo Maillard browning.
Inkompatibilitäten
Dust may form explosive mixture with air. Incompatible with strong oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, and epoxides.
Waste disposal
Consult with environmental regulatory agencies for guidance on acceptable disposal practices. Generators of waste containing this contami- nant (≥100 kg/mo) must conform to EPA regulations governing storage, transportation, treatment, and waste disposal.
Regulatory Status
Accepted for use as a food additive in Europe; ‘E954’ is applied to both saccharin and saccharin salts. Included in the FDA Inactive Ingredients Database (buccal and dental preparations; IM and IV injections; oral and topical preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

Saccharin sodium Upstream-Materialien And Downstream Produkte

1,2-Benzisothiazol-3(2H)-on-1,1-dioxid, Natriumsalz Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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