Methylisothiocyanat

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Achtung

• Gefahrenhinweise

  H301：Giftig bei Verschlucken.

  H314：Verursacht schwere Verätzungen der Haut und schwere Augenschäden.

  H317：Kann allergische Hautreaktionen verursachen.

  H335：Kann die Atemwege reizen.

  H410：Sehr giftig für Wasserorganismen mit langfristiger Wirkung.

• Sicherheit

  P260：Dampf/Aerosol/Nebel nicht einatmen.

  P273：Freisetzung in die Umwelt vermeiden.

  P280：Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.

  P303+P361+P353：BEI BERÜHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

Methyl isothiocyanate Chemische Eigenschaften,Einsatz,Produktion Methoden

• R-Sätze Betriebsanweisung:

  R23/25:Giftig beim Einatmen und Verschlucken.
  R34:Verursacht Verätzungen.
  R43:Sensibilisierung durch Hautkontakt möglich.
  R50/53:Sehr giftig für Wasserorganismen, kann in Gewässern längerfristig schädliche Wirkungen haben.

• S-Sätze Betriebsanweisung:

  S36/37:Bei der Arbeit geeignete Schutzhandschuhe und Schutzkleidung tragen.
  S38:Bei unzureichender Belüftung Atemschutzgerät anlegen.
  S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn möglich, dieses Etikett vorzeigen).
  S60:Dieses Produkt und sein Behälter sind als gefährlicher Abfall zu entsorgen.
  S61:Freisetzung in die Umwelt vermeiden. Besondere Anweisungen einholen/Sicherheitsdatenblatt zu Rate ziehen.

• Beschreibung

  Methyl iso thio cyanate is the organo sulfur compound with the formula CH₃N = C = S . This low melting colorless solid is a powerful lachrymator. As a precursor to a variety of valuable bioactive compounds, it is the most important organic iso thio cyanate in industry.

• Chemische Eigenschaften

  Colorless to tan liquid; pungent, penetrating, mustard-like odor.

• Chemische Eigenschaften

  colourless solid

• Chemische Eigenschaften

  Methyl isothiocyanate is a crystalline solid. Horseradish, acrid odor.

• Occurrence

  Reported found in horseradish.

• Verwenden

  Pesticide and soil fumigant used to control insects, soil fungi, nematodes.

• Verwenden

  Pesticide; soil fumigant.

• Verwenden

  Usually used to study the effect of pesticide Metam (methyl isothiocyanate is its active ingredient) in the streamside microbial communities of the upper Sacramento river

• Definition

  ChEBI: An isothiocyanate having a methyl group attached to the nitrogen.

• Application

  Solutions of MITC are used in agriculture as soil fumigants, mainly for protection against fungi and nematodes.
  MITC is a building block for the synthesis of 1,3,4 - thiadiazoles, which are heterocyclic compounds used as herbicides. Commercial products include "Spike", "Ustilan," and "Erbotan." Well known pharmaceuticals prepared using MITC include Zantac and Tagamet.

• Reaktionen

  A characteristic reaction is with amines to give methyl thioureas:
  CH₃NCS + R₂NH → R₂NC(S)NHCH₃
  Other nucleophiles add similarly.

• Aroma threshold values

  Very high strength odor; recommend smelling in a 0.01% solution or less

• Allgemeine Beschreibung

  A colorless liquid with a sharp odor. Lethal by inhalation of even small quantities of vapor. Does not have odor warning characteristics at low concentrations. Do not rely on the sense of smell to warn about the presence of vapors. Denser than water. Flash point below 20°F. May cause tearing and irritate the eyes, skin, nose and throat.

• Air & Water Reaktionen

  Highly flammable. Methyl isothiocyanate reacts with water to form carbon dioxide and methylamine gases.

• Reaktivität anzeigen

  Isocyanates and thioisocyanates, such as Methyl isothiocyanate, are incompatible with many classes of compounds, reacting exothermically to release toxic gases. Reactions with amines, aldehydes, alcohols, alkali metals, ketones, mercaptans, strong oxidizers, hydrides, phenols, and peroxides can cause vigorous releases of heat. Acids and bases initiate polymerization reactions in these materials. Some isocyanates react with water to form amines and liberate carbon dioxide. Polyurethanes are formed by the condensation reaction of diisocyanates with, for example, ethyl glycol.

• Hazard

  Toxic by ingestion, strong irritant to eyesand skin.

• Health Hazard

  Very toxic; probable human oral lethal dose is 50-500 mg/kg, or between 1 teaspoonful and 1 oz. for a 70 kg (150 lb.) person. Highly irritating to skin, mucous membrances, and eyes. Human oral minimum lethal dose: approximately 1 g/kg.

• Brandgefahr

  (Non-Specific -- Pesticide, Solid, n.o.s.) Methyl isothiocyanate may burn, but does not ignite readily. Fire may produce irritating or poisonous gases. When heated Methyl isothiocyanate emits very dangerous cyanides and sulfur compounds. Do not store below -4F or at elevated temperatures. Keep away from sparks.

• Flammability and Explosibility

  Non flammable

• Sicherheit(Safety)

  MITC is a dangerous lachrymator as well as being poisonous.

• Synthese

  It is prepared industrially by two routes. Annual production in 1993 was estimated to be 4M kg. The main method involves the thermal rearrangement of methyl thio cyanate :
  CH₃S - C ≡ N → CH₃N = C = S
  It is also prepared via with the reaction of methylamine with carbon disulfide followed by oxidation of the resulting dithio carbamate with hydrogen peroxide. A related method is useful to prepare this compound in the laboratory.
  MITC forms naturally upon the enzymatic degradation of gluco capparin , a modified sugar found in capers.

• mögliche Exposition

  It is used as a soil fumigant. A mixture of methyl isothiocyanate and chlorinated C-3 hydrocarbons is used as a soil fumigant for control of weeds, fungi, insects, and nematodes.

• Erste Hilfe

  If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at leastFirst Aid: If this chemical gets into the eyes, remove anycontact lenses at once and irrigate immediately for at least15 min, occasionally lifing upper and lower lids. Seek med-ical attention immediately. If this chemical contacts theskin, remove contaminated clothing and wash immediatelywith soap and water. Seek medical attention immediately. Ifthis chemical has been inhaled, remove from exposure,begin rescue breathing (using universal precautions, includ-ing resuscitation mask) if breathing has stopped and CPR ifheart action has stopped. Transfer promptly to a medicalfacility. When this chemical has been swallowed, get medi-cal attention. Give large quantities of water and inducevomiting. Do not make an unconscious person vomit.Medical observation is recommended for 24- -48 h afterbreathing overexposure, as pulmonary edema may bedelayed. As first aid for pulmonary edema, a doctor orauthorized paramedic may consider administering a cortico-steroid spray.

• Environmental Fate

  Soil. Though no products were reported, the reported half-life in soil is <14 days (Worthing and Hance, 1991).
  Chemical/Physical. Emits toxic fumes of nitrogen and sulfur oxides when heated to decomposition (Sax and Lewis, 1987).

• Stoffwechselwegen

  Methyl isothiocyanate is slowly decomposed in pure water, forming methylamine. It is metabolised in rats to the mercapturate via the glutathione conjugate which serves as a potential source of methyl isothiocyanate. Methyl isothiocyanate is reactive with cellular thiols and amines and its toxicity is associated with these reactions.

• Lager

  (1) Color Code—Red: Flammability Hazard: Storein a flammable liquid storage area or approved cabinetaway from ignition sources and corrosive and reactivematerials. (2) Color Code—Blue: Health Hazard/Poison:Store in a secure poison location. Prior to working with thischemical you should be trained on its proper handling andstorage. Store in tightly closed containers in a cool, wellventilated area. Sources of ignition, such as smoking andopen flames, are prohibited where methyl isothiocyanate isused, handled, or stored in a manner that could create apotential fire or explosion hazard. Metal containers involving the transfer of 5 gallons or more of this chemical shouldbe grounded and bonded. Drums must be equipped withself-closing valves, pressure vacuum bungs, and flamearresters. Use only nonsparking tools and equipment, especially when opening and closing containers of this chemical. Wherever this chemical is used, handled, manufactured,or stored, use explosion-proof electrical equipment andfittings.

• Versand/Shipping

  UN2477 Methyl isothiocyanate, Hazard class: 6.1; Labels: 6.1-Poison Inhalation Hazard, 3-Flammable liquid, Inhalation Hazard Zone B.

• Degradation

  Methyl isothiocyanate is unstable and reactive. It is rapidly hydrolysed by alkalis but more slowly in acidic or neutral solutions. DT₅₀ values for hydrolysis were 85,490 and 110 hours at pH 5,7 and 9, respectively. It is sensitive to oxgen and to light (PM). The relatively slow hydrolysis of methyl isothiocyanate in pure water can be accelerated by adding high concentrations of acid. Thiocarbamic acid is formed that in turn decomposes rapidly to protonated methylamine. Addition of water to the isothiocyanate N=C bond via a mechanism involving synchronous nucleophilic attack at carbon and proton transfer to nitrogen with a cyclic transition state is proposed. Methyl isothiocyanate is 10⁷ times less susceptible to acid catalysis in water than its O-analogue (Joseph et al., 1992). It will also combine with various essential nucleophilic centres in biological systems. For example, it reacts with cysteine in vitro, forming a dithiocarbamate derivative in solutions of pH greater than 6 (Goksoyr, 1964).
  The fungicide is photolysed in the gas phase with a half life of 10 hours under irradiation from a xenon arc lamp and slightly more than one day for late summer sunlight in Nevada, USA. The relatively rapid photolysis of methyl isothiocyanate had not previously been observed in other experiments in aqueous solutions where rates were 20 times slower. Products of photolysis were methyl isocyanide (2), sulfur dioxide, hydrogen sulfide, N-methylformamide (3), methylamine and carbonyl sulfide. Methyl isocyanide (2) was initially the main product and it yielded methyl isocyanate (4) (Geddes et al., 1995).

• Toxicity evaluation

  MITC stimulates chemesthesis, the activation of receptors associated with sensations of pain, touch, or thermal perception, through activation of transient receptor potential (TRPA1) ion channels. Isothiocyanate molecules have an electrophilic carbon atom that reacts with nucleophilic components, such as cysteine residues in the TRPA1 channels that are highly sensitive and serve as a warning mechanism to prevent tissue damage. MITC can form a reversible covalent bond with receptors to stimulate a reaction instead of acting directly through tissue damage. MITC is less potent than other isothiocyanates, such as allyl isothiocyanate (i.e., the active component of horseradish, wasabi, and mustard). At low concentrations, endogenous nucleophiles (e.g., GSH) may neutralize the electrophilic carbon and, therefore, prevent damage, but as concentrations increase their effectiveness decreases. Although the mode of action of MITC for systemic toxicity is not known, MITC is proposed to react with, and inactivate, the sulfhydryl group of essential enzymes in living organisms.

• Inkompatibilitäten

  Dust may form explosive mixture with air. Reacts with water, releasing carbon dioxide and methylamine gases. Unstable and reactive; sensitive to oxygen and to light. Incompatible with oxidizers (chlorates, nitrates, peroxides, permanganates, perchlorates, chlorine, bromine, fluorine, etc.); contact may cause fires or explosions. Keep away from alkaline materials, strong bases, strong acids, oxoacids, epoxides, alcohols, strong bases, amines, water, heat and cold. Attacks iron, zinc and other metals

• Waste disposal

  In accordance with 40CFR 165 recommendations for the disposal of pesticides and pesticide containers. Must be disposed properly by following package label directions or by contacting your local or federal environmental control agency, or by contacting your regional EPA office

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