Isoflupredon

Isoflupredone Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Isoflupredone, also known as deltafludrocortisone and 9α-fluoroprednisolone, is a synthetic glucocorticoid corticosteroid which was never marketed. Its acetate ester is isoflupredone acetate whch is widely used in veterinary medicine[1].

• Chemische Eigenschaften

  White Solid

• Originator

  Isoflupredon,Farmabios

• Verwenden

  Isoflupredone is an anti-inflammatory.  Isoflupredone could  be used as an internal standard in the determination of 12 glucocorticoids in bovine milk through liquid chromatography with tandem mass spectrometry[1]. It could be used to treat endometritis by increasing pregnancy rates[2]. Isoflupredone acetate is one of four Food and Drug Administration approved corticosteroids for intra-articular use in horses[3].

• Definition

  ChEBI: 9-Fluoroprednisolone is a 21-hydroxy steroid.

• Manufacturing Process

  A 100 ml broth culture containing a 0.1% yeast extract concentration, 9.0 ml of 0.2 M KH2PO4 and 9.0 ml of 0.2 M Na2HPO4 contained in a 300 ml Erlenmeyer flask, is seeded with 1 ml of a 24-h broth culture of Corynehacierium simplex (A. T, C. C. 6946). The flask is incubated at 28°C for 24 h. A second 300 ml Erlenmeyer flask containing 150 mg of sterile 9α- fluoro-4-pregnen-11β,17α,21-triol-3,20-diene in 5.0 ml acetone is inoculated with the 24 h culture of Corynebacterium simplex (A. T. C. C. 6946). The culture-containing steroid solution is incubated for 48 h at 28° to 30°C.
  The product is extracted with chloroform and isolated by evaporation to dryness. Recrytstallizstion of the residue affords 9α-fluoro-δ1,4-pregnadiene- 11β,17α,21-triol-3.20-dione as a solid.

• Therapeutic Function

  Glucocorticoid

• Einzelnachweise

  [1] Ma L, et al. Multiresidue analysis of glucocorticoids in milk by LC-MS/MS with low-temperature purification and dispersive solid-phase extraction. Journal of Separation Science, 2017; 40: 2759-2768.
  [2] Wolf C, et al. Uterine nitric oxide levels and isofluopredone treatment effect in mares susceptible to persistent post-breeding endometritis. Animal Reproduction, 2016; 13: 100-104.
  [3] Knych H, et al. Expression of inflammatory and structural matrix genes in synovial fluid following intra-articular administration of isoflupredone acetate to exercised horses. Equine Veterinary Journal, 2017; 50: 504-512.

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