1H-Imidazol-4-carbaldehyd

Bezeichnung:1H-Imidazol-4-carbaldehyd

CAS-Nr3034-50-2

Englisch Name:1H-Imidazole-4-carbaldehyde

CBNumberCB6406969

SummenformelC4H4N2O

Molgewicht96.09

MOL-Datei3034-50-2.mol

Synonyma

1H-Imidazol-4-carbaldehyd

1H-Imidazol-4-carbaldehyd physikalisch-chemischer Eigenschaften

Schmelzpunkt	174-177 °C (lit.)
Siedepunkt	367.8±15.0 °C(Predicted)
Dichte	1.322±0.06 g/cm3(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
Löslichkeit	Soluble in DMSO, methanol.
pka	11.05±0.10(Predicted)
Aggregatzustand	Solid
Farbe	Light Tan
Sensitive	Air Sensitive
InChIKey	ZQEXIXXJFSQPNA-UHFFFAOYSA-N
CAS Datenbank	3034-50-2(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-20/21/22
S-Sätze:	26-36-36/37/39
WGK Germany	3
Hazard Note	Irritant
HS Code	29332900

Gefahreninformationscode (GHS)

1H-Imidazole-4-carbaldehyde Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitsschädlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Chemische Eigenschaften
White to light yellow powder
Verwenden
1H-Imidazole-4-carbaldehyde is a 4-formyl derivative of imidazole used in the preparation of C17,20-lyase inhibitor for the treatment of androgen-dependent prostate cancer. It is also used in the synthesis of other biologically active compounds such as antimalarial drugs, fabrication of colorimetric chemosensor.
Application
1H-Imidazole-4-carbaldehyde may be used in the following studies: Synthesis of new donor-Π-acceptor (D-Π-A) type dye. Preparation of ethyl, n-dodecyl and n-hexadecyl esters of urocanic acid (4-imidazoleacrylic acid). Fabrication of colorimetric chemosensor. Synthesis of chiral nickel(II) complex, [Ni(II)H3L](ClO4)2, having an achiral ligand H3L (tris{2-(4-imidazolyl)methyliminoethyl}amine).
Synthese
To a solution of 4-bromo-1H-imidazole in dry THF at 0 ℃ was added, a 2 M solution of i-PrMgCl in THF for 5 min. The clear solution was stirred at that temperature for an additional 5 min, and a 2.5 M solution of n-BuLi in hexanes was added dropwise for 5 min while maintaining the temperature below 20 ℃. The resulting mixture was stirred at that temperature for 0.5 h, and dry DMF was added to 20℃. The mixture was warmed to 20 ℃ in 0.5 h and quenched with water (6 mL). After stirring for 10 min, the phases were separated, and the water phase was extracted one additional time with ethyl acetate. After purification to afford 1H-Imidazole-4-carbaldehyde as an off-white solid, 0.36 g (yield: 85%).

1H-Imidazole-4-carbaldehyde Upstream-Materialien And Downstream Produkte

1H-Imidazol-4-carbaldehyd Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

3034-50-2, 1H-Imidazole-4-carbaldehyde Verwandte Suche:

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