ISOTETRANDRINE

ISOTETRANDRINE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  A bisbenzylisoquinoline alkaloid, shown to be identical with berbamine methyl ether, this base occurs in A therosperrna rnoschaturn, Berberis japonica and Stephania cephalantha. It is dextrorotatory with [α]¹⁷_D + 146° or[α]²⁰_D + 150.7° (c 0.85, CHC13). When recrystallized from MeOH it forms colourless crystals and furnishes a crystalline dimethiodide, m.p. 242°C. Four methoxyl groups and two methylimino groups are present.

• Verwenden

  Isotetrandrine is a biscoclaurine alkaloid inhibitor of G protein activation of PLA2.

• target

  IL Receptor | NF-kB | MAPK | Nrf2 | HO-1 | JNK

• Einzelnachweise

  Kondo et al., J. Pharrn. Soc., Japan, 58,920 (1938)
  Tomita, Fujita, Morai., ibid, 71,226,301 (1951)
  Bick, Clezy, Crow., Austral. J. Chern., 9, III (1956)
  Synthesis:
  Inubushi et ai., Tetrahedron Lett., 3399 (1968)
  

ISOTETRANDRINE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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