2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Bezeichnung:2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

Englisch Name:2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl

CBNumberCB6344872

SummenformelC26H36NP

Molgewicht393.54

2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl physikalisch-chemischer Eigenschaften

Schmelzpunkt	121-124 °C(lit.)
Siedepunkt	539.6±43.0 °C(Predicted)
storage temp.	Keep in dark place,Sealed in dry,Room Temperature
pka	5.04±0.18(Predicted)
Aggregatzustand	crystal
Farbe	white
Wasserlöslichkeit	Insoluble
Sensitive	Air Sensitive
InChIKey	ZEMZPXWZVTUONV-UHFFFAOYSA-N
CAS Datenbank	213697-53-1(CAS DataBase Reference)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-22
S-Sätze:	26-36/37/39
WGK Germany	3
TSCA	No
HazardClass	AIR SENSITIVE
HS Code	29310099

Gefahreninformationscode (GHS)

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl is a potent inhibitor of the enzyme bromodomain. Bromodomain has been implicated in cancer and other diseases. It binds to the bromodomain in a covalent manner, blocking the ATP site and inhibiting bromodomain function. This inhibition has been shown to be selective for bromodomains over other domains.
Chemische Eigenschaften
white to light yellow crystals or
Verwenden
Effective ligand in the Pd-catalyzed arylation of ester enolates
Verwenden
suzuki reaction
Verwenden
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenyl can act as ligand used in the palladium-catalyzed Suzuki coupling and amination of unactivated aryl chlorides.
Application
2-Dicyclohexylphosphino-2'-(N,N-dimethylamino)biphenylacts as a growth regulator by binding to Toll-like receptor 4 (TLR4), which is important in cytokine signaling. It also inhibits allyl carbonate production and cross coupling reactions between aryl chlorides and nitrogen atoms or amines. It has an inhibitory effect on depression, but this effect is not related to its inhibitory effect on bromodomains.