MK-4101 Struktur

MK-4101

Bezeichnung:MK-4101

CAS-Nr935273-79-3

Englisch Name:MK-4101

CBNumberCB63123144

SummenformelC24H24F5N5O

Molgewicht493.47

MOL-Datei935273-79-3.mol

MK-4101 physikalisch-chemischer Eigenschaften

storage temp.	Store at -20°C
Löslichkeit	Soluble in DMSO
Aggregatzustand	A crystalline solid
Farbe	White to off-white

Gefahreninformationscode (GHS)

MK-4101 Chemische Eigenschaften,Einsatz,Produktion Methoden

Biologische Aktivität
mk-4101 is a hedgehog (hh) signaling pathway inhibitor.abnormal activation of the hedgehog (hh) signaling pathway is reported in the pathogenesis of various cancers, such as medulloblastoma and basal cell carcinoma.
in vitro
mk-4101 was found to target the hh pathway in tumor cells, with the maximum inhibitory effect on gli1. mk-4101 could also induce the deregulation of cell cycle and block of dna replication in tumors. in addition, members of the igf and wnt signaling pathways were among the most highly deregulated genes by mk-4101, indicating that the interplay among hh, igf, and wnt was critical in hh-dependent tumorigenesis [1].
in vivo
in a previous study, using neonatally irradiated ptch1(+/-) mice as a model of hh-dependent tumors, the in vivo effects of mk-4101 was investigated for the treatment of medulloblastoma and basal cell carcinoma. results showed a potent antitumor activity of mk-4101, achieved by the inhibition of proliferation and induction of extensive apoptosis. moreover, beside antitumor activity on transplanted tumors, mk-4101 was found to be highly efficacious against primary medulloblastoma and basal cell carcinoma in the cerebellum and skin [1].

target

IC 50

1.5 μmol/l for in mouse light ii cells by gli_luc assay

Einzelnachweise

[1] filocamo g et al. mk-4101, a potent inhibitor of the hedgehog pathway, is highly active against medulloblastoma and basal cell carcinoma. mol cancer ther. 2016 jun;15(6):1177-89.

MK-4101 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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