m-PEG10-amine

m-PEG10-amine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  m-PEG10-amine is reactive with activated NHS esters to form stable aminde bond. The hydrophilic PEG spacer increases solubility in aqueous media.

• Biologische Aktivität

  m-PEG10-amine is a non-cleavable ADC linker containing 10 units of PEG, which can be used for the synthesis of antibody drug conjugates (ADCs). It is also a PROTAC linker, belonging to the PEG class, which can be used to synthesize PROTAC molecules.

• in vitro

  ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
  PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

• target

  PEGs	Non-cleavable

m-PEG10-amine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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