4-bromo-1-ethyl-1,2-dihydropyridin-2-one

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H302：Gesundheitsschädlich bei Verschlucken.

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

4-bromo-1-ethyl-1,2-dihydropyridin-2-one Chemische Eigenschaften,Einsatz,Produktion Methoden

• Synthese

  

  36953-37-4

  

  75-03-6

  

  832735-58-7

  Under argon protection, 4-bromo-2-hydroxypyridine (1.00 g, 5.75 mmol) was dissolved in THF (20 mL) and cooled to 0°C. Sodium hydride (60% dispersion in mineral oil, 230 mg, 5.75 mmol) was slowly added to this solution and stirred for 30 min at room temperature. Subsequently, ethyl iodide (1.39 mL, 17.25 mmol) was added and the reaction mixture was stirred at room temperature for 16 hours and then heated at 50°C for 24 hours. After completion of the reaction, the mixture was diluted with water and ethyl acetate. The organic layer was separated, washed sequentially with water and brine, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: DCM/EtOAc, 100/0 to 85/15) to afford the target product 4-bromo-1-ethylpyridin-2(1H)-one (981 mg, 4.86 mmol, 84% yield).

• Einzelnachweise

  [1] Patent: EP2913330, 2015, A1. Location in patent: Paragraph 0546

4-bromo-1-ethyl-1,2-dihydropyridin-2-one Upstream-Materialien And Downstream Produkte

4-bromo-1-ethyl-1,2-dihydropyridin-2-one Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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