CYCLOSPORIN D

Bezeichnung:CYCLOSPORIN D

CAS-Nr63775-96-2

Englisch Name:CYCLOSPORIN D

CBNumberCB6276179

SummenformelC63H113N11O12

Molgewicht1216.64

MOL-Datei63775-96-2.mol

CYCLOSPORIN D physikalisch-chemischer Eigenschaften

Schmelzpunkt	148-1510C
alpha	D20 -245° (c = 0.52 in CHCl3); D20 -211° (c = 0.51 in methanol)
Siedepunkt	1294.7±65.0 °C(Predicted)
Dichte	1.015±0.06 g/cm3(Predicted)
Flammpunkt	9 °C
storage temp.	-20°C Freezer
Löslichkeit	Chloroform (Sparingly), Ethyl Aceatate (Slightly), Methanol (Slightly)
Aggregatzustand	Colorless to off-white crystalline solid.
pka	13.22±0.70(Predicted)
Farbe	White to Off-White
InChIKey	YJDYDFNKCBANTM-QCWCSKBGSA-N

Sicherheit

Kennzeichnung gefährlicher	F,Xn,T
R-Sätze:	11-20/21/22-36-39/23/24/25-23/24/25
S-Sätze:	16-36/37-45-7
RIDADR	UN 1648 3 / PGII
WGK Germany	2
HS Code	29419090

Gefahreninformationscode (GHS)

CYCLOSPORIN D Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Colorless Crystalline Solid
Verwenden
A group of nonpolar cyclic oligopeptides with immunosupppressant activity.
Verwenden
Cyclosporin D is a minor analogue of the cyclosporin family which is only weakly immunologically active. Cyclosporin D is a potent inhibitor of tumour-promoting phorbol esters on mouse skin in vivo, and a potent inhibitor of calcium/calmodulin-dependent EF-2 phosphorylation in vitro.
Biologische Aktivität
cyclosporin d is an immunosuppressive agent [1].cyclosporin d (csd) is an analogue of cyclosporine a with weak immunosuppressive activity. cyclosporin d has been used as an internal standard for the quantification of cyclosporin a. in human multidrug-resistant ovarian cancer cells, cyclosporin d significantly overcame adriamycin resistance [2]. in lymphocyte, csd weakly inhibited pha-, pwm-, and pma + ca2+-induced cell proliferation [3].in mice, csd inhibited edema in mouse ear and alkaline phosphatase activity in mouse skin induced by tpa by 98% and 88%, respectively. in cytosol of mouse pancreas, csd inhibited the ca2+/calmodulin-dependent phosphorylation of the elongation factor 2 (ef-2) and the tpa-induced increase of ef-2 [1]. cyclosporin d was effective in inhibiting p. falciparum parasite in vitro and p. berghei malaria parasite development in vivo when administered orally [4].
Lager
+4°C
Einzelnachweise
[1]. gschwendt m, kittstein w, marks f. the weak immunosuppressant cyclosporine d as well as the immunologically inactive cyclosporine h are potent inhibitors in vivo of phorbol ester tpa-induced biological effects in mouse skin and of ca2+/calmodulin dependent ef-2 phosphorylation in vitro. biochem biophys res commun, 1988, 150(2): 545-551.
[2]. mizuno k, furuhashi y, misawa t, et al. modulation of multidrug resistance by immunosuppressive agents: cyclosporin analogues, fk506 and mizoribine. anticancer res, 1992, 12(1): 21-25.
[3]. sadeg n, pham-huy c, rucay p, et al. in vitro and in vivo comparative studies on immunosuppressive properties of cyclosporines a, c, d and metabolites m1, m17 and m21. immunopharmacol immunotoxicol, 1993, 15(2-3): 163-177.
[4]. uadia po1, ezeamuzie ic, ladan mj, et al. antimalarial activity of cyclosporins a, c and d. afr j med med sci, 1994, 23(1): 47-51.

CYCLOSPORIN D Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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