GASTRIN RELEASING PEPTIDE, HUMAN Struktur

GASTRIN RELEASING PEPTIDE, HUMAN

Bezeichnung:GASTRIN RELEASING PEPTIDE, HUMAN

CAS-Nr93755-85-2

Englisch Name:GASTRIN RELEASING PEPTIDE, HUMAN

CBNumberCB6271275

SummenformelC130H204N38O31S2

Molgewicht2859.38

MOL-Datei93755-85-2.mol

GASTRIN RELEASING PEPTIDE, HUMAN physikalisch-chemischer Eigenschaften

Dichte	1.46±0.1 g/cm3(Predicted)
storage temp.	−20°C
Aggregatzustand	Powder
Farbe	White to off-white
Wasserlöslichkeit	Soluble to 1 mg/ml in water
Sequenz	H-Val-Pro-Leu-Pro-Ala-Gly-Gly-Gly-Thr-Val-Leu-Thr-Lys-Met-Tyr-Pro-Arg-Gly-Asn-His-Trp-Ala-Val-Gly-His-Leu-Met-NH2

Sicherheit

WGK Germany

GASTRIN RELEASING PEPTIDE, HUMAN Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
Gut-brain peptides are widely conserved in vertebrates, GRP is a neuropeptide that modulates the autonomic system. It is an anorexigenic factor in the brain, regulates male sexual function at the spinal cord level, conveys the itch sensation, and is also involved in many autonomic regulations in the brain. The expression of GRP is also a specific tumor marker for small cell lung cancer. It has the GXHWAVGHLM amide (X=N or S) sequence at its C-terminus.
Verwenden
GRP (gastrin releasing peptide) has been used for absorption/neutralization of anti-GRP antibody prior to the tyramide signal amplification (TSA) procedure.
Allgemeine Beschreibung
GRP (gastrin releasing peptide) is the mammalian homolog of bombesin (BBS) and functions as a mitogen for multiple cancers, such as neuroblastoma. It is a ligand for GRPR (GRP receptor) and is expressed in a subtype of peptidergic dorsal root ganglion neurons.
Biochem/physiol Actions
GRP (gastrin releasing peptide) functions as an autocrine growth factor for nueroblastoma. It facilitates cell survival in PI3K/AKT (phosphatidylinositol-3-kinase/ v-Akt murine thymoma viral oncogene)-mediated manner and cell proliferation and angiogenesis in neuroblastoma. This peptide is involved in the release of gastrin and the control of gastric acid secretion and motor function. In patients with atopic dermatitis, the serum levels of this peptide are linked with pruritus.
Clinical Use
GRP mRNA is overexpressed in patients suffering from small cell lung cancer. Clinically, therefore, a higher level of circulating proGRP31–125 is a specific tumor marker for small cell lung cancer (higher than ~81.0 pg/mL in the plasma). In addition, intravenous infusions of GRP decrease spontaneous food intake in healthy men, suggesting GRP acts as a satiety signal in humans. GRP has not yet been used much clinically as a therapeutic agent.
Lager
Store at -20°C

GASTRIN RELEASING PEPTIDE, HUMAN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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