5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride

Gefahreninformationscode (GHS)

• Bildanzeige (GHS)

  

• Alarmwort

  Warnung

• Gefahrenhinweise

  H315：Verursacht Hautreizungen.

  H319：Verursacht schwere Augenreizung.

  H335：Kann die Atemwege reizen.

• Sicherheit

  P261：Einatmen von Staub vermeiden.

  P305+P351+P338：BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.

5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride can be used as organic synthesis intermediate and pharmaceutical intermediate, mainly used in laboratory research and development process and chemical production process.

• Synthese

  
  5,6,7,8-Tetrahydro-[1,7]napthyridine hydrochloride. A methanolic solution (25 mL) of 7-Benzyl-5,6,7,8-tetrahydro-[1,7]naphthyridine (J. Het. Chem. 2001, 38, 535) (1.5g, 6.69 mmol) was degassed with argon for 20 min followed by the addition of 4N HCl in dioxane (2 mL) and Pd/C (300 mg, 20 wt%) and stirred under 50 psi hydrogen pressure at room temperature for 24h. After completion of the reaction the mixture was filtered on a short pad of celite and washed with methanol (4 × 25 mL). The filtrate was evaporated to dryness in vacuo and crystallized from methanol. Yield: 65% (calculated as 2HCl salt), 900 mg, yellowish solid.

5,6,7,8-Tetrahydro-1,7-naphthyridine hydrochloride Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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