Terpendole E

Terpendole E Chemische Eigenschaften,Einsatz,Produktion Methoden

• Verwenden

  Acyl-coenzyme A:cholesterol acyltransferase (ACAT) isozymes are involved with cellular cholesterol esterification and regulate intestinal cholesterol absorption and hepatic lipoprotein secretion. Terpendole E is a related compound of Terpendole C (T116600), which is an inhibitor of ACAT1 and ACAT2 isozymes.

• Definition

  ChEBI: Terpendole E is an organic heterotricyclic compound and an organooxygen compound.

• Biochem/physiol Actions

  Terpendole E is a mitotic kinesin Eg5 (Kinesin-5) inhibitor isolated from Albophoma yamanashiensis that inhibits both motor and microtubule stimulated ATPase activities of human Eg5. Studies indicate that Terpendole E inhibits Eg5 mutants resistant to S-trityl-L-cysteine and other Eg5 inhibitors. Also, Terpendole E is an ACAT (Acyl-CoA:cholesterol acyltransferase) inhibitor.

Terpendole E Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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