SIRT2 Inhibitor, Inactive Control, AGK7

SIRT2 Inhibitor, Inactive Control, AGK7 Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  AGK2 is a cell-permeable, selective inhibitor of SIRT2 (IC₅₀ = 3.5 μM) that minimally affects either SIRT1 or SIRT3 at 10-fold higher levels. AGK7 is an inactive control to be used in experiments with AGK2. It differs from AGK2, structurally, only in the position of nitrogen in the quinoline group. AGK7 has IC₅₀ values greater than 50 μM on SIRT1 and SIRT2 and greater than 5 μM on SIRT3.

• Einzelnachweise

  [1]. outeiro tf, kontopoulos e, altmann sm, et al. sirtuin 2 inhibitors rescue alpha-synuclein-mediated toxicity in models of parkinson's disease. science. 2007 jul 27;317(5837):516-9.
  [2]. cole pa. chemical probes for histone-modifying enzymes. nat chem biol. 2008 oct;4(10):590-7.

SIRT2 Inhibitor, Inactive Control, AGK7 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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