Grape Seed Extract

Bezeichnung:Grape Seed Extract

CAS-Nr84929-27-1

Englisch Name:Grape Seed Extract

CBNumberCB6258001

SummenformelC32H30O11

Molgewicht590.574

MOL-Datei84929-27-1.mol

Grape Seed Extract physikalisch-chemischer Eigenschaften

Dichte	0.961g/cm3 at 20℃
Dampfdruck	0.003Pa at 60℃
FEMA	4045 \| GRAPE SEED EXTRACT
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Soluble in DMSO
Aggregatzustand	Solid:particulate/powder
LogP	6.5 at 25℃ and pH5-6

Gefahreninformationscode (GHS)

Grape Seed Extract Chemische Eigenschaften,Einsatz,Produktion Methoden

Chemische Eigenschaften
Grape seed extract has an astrigent taste.
Occurrence
Grapeseed is found throughout the world.
Verwenden
Grapeseed may be used as an antioxidant and an anticancer treatment. It may also be used to treat varicose veins, circulatory problems, and vision problems such as cataracts, and to improve vision by lessening eye strain.
Verwenden
Grape seed extract is a natural product, with anti-inflammatory and anti-proliferative effects. Grape seed extract shows inhibitory activity on the fat-metabolizing enzymes pancreatic lipase and lipoprotein lipase. Grape seed extract induces apoptotic in human colorectal cancer cells.
Composition
Standardized grape seed extracts are reported to contain 74 to 78% oligomeric proanthocynidins and less than approx- imately 6% of free favanol monomers on a dry weight basis Specifcally, grape seed extract contains the favanol monomers (+)-cat- echin, (–)-epicatechin, (–)-epicatechin gallate, (–)-epigallocatechin and (–)-epigallocatechin gallate.
Anticancer Research
Grape seed extract (GSE) has high quantities of proanthocyanidins and resveratrol.Human colorectal cancer cell (CRC) exposure to GSE (Schonthal 2012) resulted inmodified ER chaperones glucose-related protein-78 (GRP78) and protein disulphideisomerase (PDI). GRP78 is needed for integrity of ER as well as stress-inducedautophagy (Flaumenhaft et al. 2015). PDI, a thiol-disulphide oxidoreductase,catalyses the disulphide bonds in newly synthesized proteins in the ER lumen (Hanet al. 2013; Wang and Kaufman 2014; Perri et al. 2016), and PDIA3 is localized tothe ER and is involved in protein folding (Wang et al. 2012b). Studies on the role ofPDI in cancer have demonstrated a pro-oncogenic, pro-survival role for PDI incancer and therapeutic resistance. PDI aids in ameliorating stress-induced apoptosisand causes degradation of wrongly folded proteins (Dinicola et al. 2010; Xu et al.2014). Hence, any obstruction caused in the activity of PDI will induce stress in thecell and lead to cell apoptosis. Fructose bisphosphate aldolase, a key enzymeinvolved in glycolysis, is also a potential target of GSE (Vandewynckel et al. 2016).The ER stress leads the cell to undergo apoptotic pathways in multiple ways andhence inhibits the proliferation of the targeted cells (Farooqi et al. 2015).

Grape Seed Extract Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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