GlyH-101 Struktur

GlyH-101

Bezeichnung:GlyH-101

CAS-Nr328541-79-3

Englisch Name:GlyH-101

CBNumberCB62446668

SummenformelC19H15Br2N3O3

Molgewicht493.15

MOL-Datei328541-79-3.mol

GlyH-101 physikalisch-chemischer Eigenschaften

Schmelzpunkt	>300℃ (ethanol )
Dichte	1.73±0.1 g/cm3(Predicted)
storage temp.	= -70C
Löslichkeit	DMF:30.0(Max Conc. mg/mL);60.83(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);1.01(Max Conc. mM) DMSO:57.58(Max Conc. mg/mL);116.75(Max Conc. mM)
Aggregatzustand	Yellow solid
pka	5.44±0.45(Predicted)
Farbe	Light yellow to yellow

GlyH-101 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung
The cystic fibrosis (CF) gene encodes a cAMP-regulated chloride channel, the CF transmembrane conductance regulator (CFTR). CFTR inhibitor II, also known as GlyH-101, is a glycine hydrazide that selectively and reversibly blocks the CFTR channel (K_i = 4.3 μM). This compound binds to a site at the external pore of CFTR, occluding the pore and rapidly preventing chloride transport. Intraluminal CFTR inhibitor II greatly reduces intestinal fluid secretion induced by cholera toxin. It is effective in cells in culture and also in nasal and intestinal epithelia in vivo.
Verwenden
N-2-Naphthalenyl-glycine 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a glycine hydrazide that has recently been shown to block CFTR channels. However, its effects on cardiomyocytes are unknown. Studies have demonstrated that GlyH-101 blocks cardiac I Cl.PKA channels in a similar fashion to that reported for recombinant CFTR.
Definition
ChEBI: Glycine, n-2-naphthalenyl-, 2-[(3,5-dibromo-2,4-dihydroxyphenyl)methylene]hydrazide is a member of naphthalenes.
Allgemeine Beschreibung
A cell-permeable glycinyl hydrazone compound that acts as a potent, selective and reversible open-channel blocker of CFTR with intermediate speed (<1 min; 95% inhibition at 50 μM; K_i = 4.3 μM in CFTR-expressing FRT cells for apical membrane Cl^- current) and exhibits desirable aqueous solubility. Shown to produce inwardly rectifying CFTR Cl^- currents with reduced mean channel open time and suggested to directly interact with the channel pore at the extracellular side of the membrane. Displays minimal effects on P-glycoprotein and non-CFTR-mediated Cl^- currents, and is effective in nasal and intestinal epithelia in vivo.
Biochem/physiol Actions
Cell permeable: yes
Lager
Store at -20°C

GlyH-101 Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Send Inquriy