ISOCORYDINE HYDROCHLORIDE

ISOCORYDINE HYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

• Beschreibung

  Isocorydine is an aporphine alkaloid that has been found in A. squamosa that has vasodilatory and anticancer activities. It reduces the action potential duration and increases the effective refractory period in isolated canine Purkinje fibers when used at a concentration of 30 μM. Isocorydine induces relaxation of norepinephrine-precontracted isolated rabbit aortic strips with an EC₅₀ value of 12.6 μM. It is cytotoxic to A549 lung cancer cells (IC₅₀ = 197.7 μM), as well as Huh7, HepG2, SNU-449, and SNU-387 hepatic cancer cells (IC₅₀s = 161.3, 148, 262.2, and 254.1 μg/ml, respectively). Isocorydine, in combination with doxorubicin, reduces tumor growth in a Huh7 mouse xenograft model.

• Verwenden

  Isocorydine is an alkaloid inhibitor of eukaryotic kinases.

• Verwenden

  sedative, cholinergic

• Verwenden

  Isocorydine Hydrochloride is the hydrochloric acid of Isocorydine(I797000) which is an alkaloid inhibitor of eukaryotic kinases.

• Definition

  ChEBI: Isocorydine is an aporphine alkaloid.

• target

  Dopamine Receptor | P450 (e.g. CYP17)

• Einzelnachweise

  See Isocorydine

ISOCORYDINE HYDROCHLORIDE Upstream-Materialien And Downstream Produkte

ISOCORYDINE HYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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