Docosan-1-ol

Bezeichnung:Docosan-1-ol

CAS-Nr661-19-8

Englisch Name:n-Docosanol

CBNumberCB6219657

SummenformelC22H46O

Molgewicht326.6

MOL-Datei661-19-8.mol

Synonyma

Docosan-1-ol

Docosan-1-ol physikalisch-chemischer Eigenschaften

Schmelzpunkt	65-72 °C(lit.)
Siedepunkt	180 °C0.22 mm Hg(lit.)
Dichte	d75 0.8063 g/ml; d85 0.7986 g/ml; d95 0.7911 g/ml
Dampfdruck	0Pa at 25℃
Brechungsindex	n75 1.4360
storage temp.	Store below +30°C.
Löslichkeit	Chloroform (Slightly), Ethyl Acetate (Slightly)
pka	15.20±0.10(Predicted)
Aggregatzustand	Pellets or Tablets
Farbe	White
Wasserlöslichkeit	Insoluble
Merck	13,3433
BRN	1770470
Stabilität	Stable. Combustible. Incompatible with strong oxidizing agents.
LogP	8.3 at 20℃
CAS Datenbank	661-19-8(CAS DataBase Reference)
NIST chemische Informationen	1-Docosanol(661-19-8)
EPA chemische Informationen	1-Docosanol (661-19-8)

Sicherheit

S-Sätze:	24/25
WGK Germany	-
RTECS-Nr.	JR1315000
TSCA	Yes
HS Code	29051900
Giftige Stoffe Daten	661-19-8(Hazardous Substances Data)
Toxizität	LD50 intraperitoneal in mouse: > 800mg/kg

Gefahreninformationscode (GHS)

n-Docosanol Chemische Eigenschaften,Einsatz,Produktion Methoden

S-Sätze Betriebsanweisung:
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
1-DOCOSANOL is white powder
Verwenden
n-Docosanol is a binder and an emulsion stabilizer. It is also used to increase a formulation’s viscosity. This is a mixture of fatty alcohols. behenyl alcohol may be used for any number of purposes in a cosmetic formulation, including as an emollient, a binder, an emulsion stabilizer, or to increase a product’s viscosity. It may be derived either synthetically or from plants.
Verwenden
1-Docosanol works as a surfactant in cosmetics. 1-Docosanol cream has also been approved by the US Food and Drug Administration as a safe and effective topical treatment for herpes labialis
Verwenden
antiviral
Indications
Docosanol (Abreva) is a long-chain saturated alcohol that is clinically effective against HSV. It has in vitro activity against many enveloped viruses, including CMV, influenzavirus, and respiratory syncytial virus.
Docosanol is not directly virucidal; instead, it blocks the entry of the virion into the host cell by inhibiting the fusion of the viral envelope with the host plasma membrane. Because it does not affect viral replication or protein production, it may be less susceptible to the development of resistance than other antiviral drugs.
Definition
1-DOCOSANOL is a long-chain, saturated fatty alcohol.
Allgemeine Beschreibung
1-Docosanol inhibits replication of certain viruses (herpes simplex virus and respiratory syncytial virus) within primary target cells in vitro. It has been isolated from Clematis brevicaudata.
Flammability and Explosibility
Not classified
Pharmazeutische Anwendungen
1-DOCOSANOL is a 22-carbon straight chain alcohol licensed for over-thecounter sales for the topical treatment of herpes labialis. It is thought to act by blocking viral fusion with the host cell, although definitive studies are lacking. The clinical relevance of the antiviral activity has been debated and the place of this medication as a treatment of herpes labialis remains to be established.
Clinical Use
Docosanol cream is approved for the over-the-counter treatment of herpes labialis. It shortens the duration of symptoms of cold sores and fever blisters but does not provide symptomatic relief.
Nebenwirkungen
Adverse effects of docosanol are minimal. Skin irritation occurs infrequently. Drug interactions are not anticipated.
läuterung methode
Crystallise docosanol from ether or chloroform/ether. [Beilstein 1 IV 1906.]

n-Docosanol Upstream-Materialien And Downstream Produkte

Docosan-1-ol Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

661-19-8, n-Docosanol Verwandte Suche:

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