4-Nitrophthalsureanhydrid

Bezeichnung:4-Nitrophthalsureanhydrid

CAS-Nr5466-84-2

Englisch Name:4-Nitrophthalic anhydride

CBNumberCB6207807

SummenformelC8H3NO5

Molgewicht193.11

MOL-Datei5466-84-2.mol

Synonyma

4-Nitrophthalsureanhydrid

4-Nitrophthalsureanhydrid physikalisch-chemischer Eigenschaften

Schmelzpunkt	116-120 °C(lit.)
Siedepunkt	197 °C / 8mmHg
Dichte	1.6392 (rough estimate)
Brechungsindex	1.4700 (estimate)
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	Acetone (Slightly), Chloroform (Slightly), Methanol (Slightly)
Aggregatzustand	Solid
Farbe	Pale Beige
Wasserlöslichkeit	Hydrolysis
Sensitive	Moisture Sensitive
BRN	179682
CAS Datenbank	5466-84-2(CAS DataBase Reference)
NIST chemische Informationen	4-Nitrophthalic anhydride(5466-84-2)
EPA chemische Informationen	5-Nitrophthalic anhydride (5466-84-2)

Sicherheit

Kennzeichnung gefährlicher	Xi,Xn
R-Sätze:	36/37/38-20/22
S-Sätze:	26-36-36/37/39-22
WGK Germany	3
RTECS-Nr.	TI3328000
F	10-21
TSCA	Yes
HS Code	29173990

Gefahreninformationscode (GHS)

4-Nitrophthalic anhydride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/22:Gesundheitsschädlich beim Einatmen und Verschlucken.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S22:Staub nicht einatmen.
Chemische Eigenschaften
off-white to light yellow-brown powder. Soluble in hot alcohol, hot acetic acid and acetone, insoluble in water.
Verwenden
4-Nitrophthalic anhydride is used an an intermediate for the synthesis of a benzimidazole PARP inhibitor I (succinate salt) (ABT-472).
Verwenden
5-Nitrophthalic Anhydride is used in the preparation of phthalic acids as well as compounds with anticonvulsant activities.
synthetische
4-Nitrophthalic anhydride is synthesized by hydrolysis of 4-nitrophthalimide and then dehydration. The 4-nitrophthalimide was added to the sodium hydroxide solution, heated and boiled for 15min. Adjust pH to 6-8 with nitric acid, and add nitric acid to boil for 5 min. Cooling, filtering, the filtrate was extracted with ether, the extract was dried and then the ether was evaporated, that is, 4-Nitrophthalic anhydride crystals were precipitated. Yield 95%.
Allgemeine Beschreibung
Yellow powder.
Air & Water Reaktionen
Reacts with water. The organic acids produced by this reaction are significantly more soluble in water.
Reaktivität anzeigen
4-Nitrophthalic anhydride reacts exothermically with water. The reactions are usually slow, but might become violent if local heating accelerates their rate. Acids accelerate the reaction with water. Incompatible with acids, strong oxidizing agents, alcohols, amines, and bases.
Brandgefahr
Flash point data for 4-Nitrophthalic anhydride are not available, however 4-Nitrophthalic anhydride is probably combustible.
läuterung methode
Distil the anhydride in a vacuum and/or recrystallise it from *C6H6 or Et2O/pet ether. Dry it in vacuo. It forms addition compounds with anthracene (m 118o), and phenanthrene (m 96o). [Beilstein 17 III/IV 6150, 17/11 V 267.]
Vorsichtsmaßnahmen
Moisture Sensitive. Store away from strong bases and oxidizing agents. Incompatible with water, bases, strong acids and oxidizing agents.

4-Nitrophthalic anhydride Upstream-Materialien And Downstream Produkte

4-Nitrophthalsureanhydrid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

5466-84-2, 4-Nitrophthalic anhydride Verwandte Suche:

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