ASP-ARG-VAL-TYR-ILE-HIS-PRO Struktur

ASP-ARG-VAL-TYR-ILE-HIS-PRO

Bezeichnung:ASP-ARG-VAL-TYR-ILE-HIS-PRO

CAS-Nr51833-78-4

Englisch Name:ASP-ARG-VAL-TYR-ILE-HIS-PRO

CBNumberCB6196808

SummenformelC41H62N12O11

Molgewicht899

MOL-Datei51833-78-4.mol

ASP-ARG-VAL-TYR-ILE-HIS-PRO physikalisch-chemischer Eigenschaften

Schmelzpunkt	>202°C (dec.)
Dichte	1.47±0.1 g/cm3(Predicted)
storage temp.	−20°C
Löslichkeit	DMSO (Slightly), Methanol (Slightly), Water (Slightly, Sonicated)
Aggregatzustand	powder
pka	3.29±0.20(Predicted)
Farbe	White to Off-White
Wasserlöslichkeit	Soluble to 1 mg/ml in water

Sicherheit

WGK Germany

Gefahreninformationscode (GHS)

ASP-ARG-VAL-TYR-ILE-HIS-PRO Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden
Angiotensin (1-7) can be used in biological study and engineering or chemical process of mechanisms of peptide oxidation by hydroxyl radicals.
Definition
ChEBI: Ile(5)-angiotensin II (1-7) is an angiotensin compound consisting of the linear heptapeptide sequence L-Asp-L-Arg-L-Val-L-Tyr-L-Ile-L-His-L-Pro. It has a role as a vasodilator agent. It is a tautomer of an Ile(5)-angiotensin II (1-7) dizwitterion.
Biologische Aktivität
ang-(1-7) (h - asp - arg - val - tyr - ile - his - pro - oh) is an endogenous peptide fragment that can be produced from ang i or ang ii via endo- or carboxy-peptidases respectively[1].as described for ang ii, ang-(1-7) also has a broad range of effects in different organs and tissues and goes beyond its initially described cardiovascular and renal actions. those effects are mediated by mas and can counter-regulate most of the deleterious effects of ang ii. the interaction ang-(1-7)/mas regulates different signaling pathways, such as pi3k (phosphoinositide 3-kinase)/akt and erk (extracellular signal-regulated kinase) pathways and involves downstream effectors such as no, foxo1 (forkhead box o1) and cox-2 (cyclo-oxygenase-2). through these mechanisms, ang-(1-7) is able to improve pathological conditions including fibrosis and inflammation in organs such as lungs, liver and kidney. [2]in addition, this heptapeptide has positive effects on metabolism, increasing the glucose uptake and lipolysis while decreasing insulin resistance and dyslipidemia. ang-(1-7) is also able to improve cerebroprotection against ischemic stroke, besides its effects on learning and memory. the reproductive system can also be affected by ang-(1-7) treatment, with enhanced ovulation, spermatogenesis and sexual steroids synthesis. finally, ang-(1-7) is considered a potential anti-cancer treatment since it is able to inhibit cell proliferation and angiogenesis.[2]fig. 1: formula of angiotensin (1-7)fig. 2: cascade of the processing of angiotensin peptides and their interaction with at1 and at1-7 receptor systems.
Biochem/physiol Actions
Angiotensin I metabolite that is an AT2 receptor agonist.
Lager
Store at -20°C
Einzelnachweise
1. Santos et al (2000) Angiotensin-(1-7): an update. Regul.Pept. 91 45.2. Danielle G. P., Thiago V., Robson A. S. Angiotensin-(1-7): beyond the cardio-renal actions. Clinical Science (2013) 124, (443–456)

ASP-ARG-VAL-TYR-ILE-HIS-PRO Upstream-Materialien And Downstream Produkte

ASP-ARG-VAL-TYR-ILE-HIS-PRO Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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