N,N-Dimethyl-3-oxobutyramid

Bezeichnung:N,N-Dimethyl-3-oxobutyramid

CAS-Nr2044-64-6

Englisch Name:N,N-Dimethylacetoacetamide

CBNumberCB6181037

SummenformelC6H11NO2

Molgewicht129.16

MOL-Datei2044-64-6.mol

Synonyma

N,N-Dimethyl-3-oxobutyramid

N,N-Dimethyl-3-oxobutyramid physikalisch-chemischer Eigenschaften

Schmelzpunkt	-55 °C
Siedepunkt	105 °C(lit.)
Dichte	1.067 g/mL at 25 °C
Dampfdruck	19.84hPa at 25℃
Brechungsindex	n20/D 1.447
Flammpunkt	252 °F
storage temp.	Inert atmosphere,Room Temperature
Löslichkeit	H2O: soluble
pka	12.82±0.46(Predicted)
Aggregatzustand	clear liquid
Farbe	APHA: ≤350
Wasserlöslichkeit	hydrolysis SLOWLY
BRN	1755038
LogP	0.91 at 25℃
CAS Datenbank	2044-64-6(CAS DataBase Reference)
NIST chemische Informationen	N,N-Dimethylacetoacetamide(2044-64-6)
EPA chemische Informationen	Butanamide, N,N-dimethyl-3-oxo- (2044-64-6)

Sicherheit

Kennzeichnung gefährlicher	N
R-Sätze:	36/37/38-51/53
S-Sätze:	26-36-61
RIDADR	UN 3082 9 / PGIII
WGK Germany	-
RTECS-Nr.	AK4035000
HS Code	2924.19.1150

Gefahreninformationscode (GHS)

N,N-Dimethylacetoacetamide Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
S-Sätze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Chemische Eigenschaften
Clear, colorless to yellow liquid
Verwenden
N,N-Dimethyl-3-oxobutanamide is used as a reactant in the asymmetric hydrogenation of functionalized ketones in presence of chiral bis(diphenylphosphino)binaphthyl ruthenium complex.
Verwenden
N,N-Dimethylacetamide is used as intermediate for the production of insecticides, e.g. dicrotophos and as a promoter in unsaturated polyester resins. Product Data Sheet
Allgemeine Beschreibung
The product is an 80% solution of N,N-dimethylacetoacetamide (DMAA) in water.
Flammability and Explosibility
Non flammable
Toxikologie
N,N-Dimethylacetoacetamide (DMAAm) is a β-dicarbonyl compound that is utilized as a co-promoter in the production of unsaturated polyester resins used in coating materials and as an industrial intermediate in insecticide synthesis. Patents have also been issued for its use in hair colorants. However, DMAAm had limited toxicology and information available. DMAAm appears to have low toxicity in rodents. Smyth et al. reported an oral LD50 in male CarworthWistar rats of 22.6mL/kg (estimated to be approximately 19.8g/kg) and a dermal LD50 in male New Zealand rabbits of 14.1mL/kg (12.4g/kg) (single 8-h exposure). Oral gavage administration of DMAAm did not result in any mortality in rats (strain and gender not reported) at doses up to 3.2g/kg. DMAAm has been identified as a hydrolytic product and a degradation product of the insecticide dicrotophos ((dimethoxyphosphinyloxy)-N, N-dimethylcis-crotonamide) in soil, but was not found as a urinary metabolite of this insecticide in rats[1].
Einzelnachweise
[1] Timothy Fennell. “Disposition and metabolism of N,N-dimethylacetoacetamide in male F344 and Wistar-Han rats and female B6C3F1 mice.” Xenobiotica 41 11 (2011): 1013–20.

N,N-Dimethylacetoacetamide Upstream-Materialien And Downstream Produkte

N,N-Dimethyl-3-oxobutyramid Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

2044-64-6, N,N-Dimethylacetoacetamide Verwandte Suche:

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