Morphine Sulfate

Bezeichnung:Morphine Sulfate

CAS-Nr6211-15-0

Englisch Name:Morphine Sulfate

CBNumberCB6140018

SummenformelC34H50N2O15S

Molgewicht758.83

MOL-Datei6211-15-0.mol

Morphine Sulfate physikalisch-chemischer Eigenschaften

Schmelzpunkt	>240°C (dec.)
storage temp.	Controlled Substance, -20°C Freezer
Löslichkeit	ethanol: 1.8 mg/mL
Aggregatzustand	A crystalline solid
BCS Class	3/1

Sicherheit

Kennzeichnung gefährlicher	Xn
R-Sätze:	22
S-Sätze:	22-36
RIDADR	UN 1544 6.1/PG 2
WGK Germany	3
RTECS-Nr.	QC8760000
HS Code	2939110000

Gefahreninformationscode (GHS)

Morphine Sulfate Chemische Eigenschaften,Einsatz,Produktion Methoden

R-Sätze Betriebsanweisung:
R22:Gesundheitsschädlich beim Verschlucken.
S-Sätze Betriebsanweisung:
S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Morphine (sulfate hydrate) (Item No. 25955) is an analytical reference standard categorized as an opioid. It is a natural phenanthrene commonly used for its analgesic properties but has a high potential for addiction. Morphine is regulated as a Schedule II compound in the United States. This product is intended for research and forensic applications.
Chemische Eigenschaften
White Solid
Originator
Avinza,Aetna Inc.
Verwenden
Principle alkaloid of opium. This is a controlled substance (opiate). Analgesic (narcotic).
Verwenden
Principal alkaloid of opium. This is a controlled substance (opiate). Analgesic (narcotic)
Definition
ChEBI: Morphine sulfate pentahydrate is an alkaloid sulfate salt and a hydrate. It contains a morphine.
Manufacturing Process
Morphin was extracted from the plant vegetable (the poppy) by the mixture of water and methanol or the aqueous solution of potassium pyrosulfate. The precipitation of the morphin was carried out by addition to the extract the aqueous solution of sodium carbonate.
Morphin can be obtained from the extract by using the cation exchanger.
Free base of morphin was transformated to the sulfate salt.
Trademarks
Astramorph (AstraZeneca); Avinza (Ligand); Depodur (Skyepharma); Duramorph (Baxter Healthcare); Infumorph (Baxter Healthcare); Kadian (Alpharma); Ms Contin (Purdue Frederick); Oramorph (Xanodyne).
Therapeutic Function
Narcotic analgesic, Sedative
Acquired resistance
The analgesic effect of orally dosed morphine can equal that obtained by parenteral administration, if proper doses are given. When given orally, the initial dose of morphine is usually 60 mg, followed by maintenance doses of 20 to 30 mg every 4 hours. Addiction to clinically used morphine by the oral route generally is not a problem.
Mechanism of action
Morphine sulfate is the analgesic used most often for severe, acute, and chronic pain. Morphine is a μ agonist and is a Schedule II drug. It is available in intramuscular, subcutaneous, oral, rectal, epidural, and intrathecal dosage forms. The epidural and intrathecal preparations are formulated without a preservative.Morphine is three- to six times more potent when given intramuscularly than when given orally. The difference in activity results from extensive first-pass 3-O-glucuronidation of morphine—an inactive metabolite. The half-life of intramuscularly dosed (10 mg) morphine is approximately 3 hours. The dose of morphine, by any dosage route, must be reduced in patients with renal failure and in geriatric and pediatric patients. The enhanced effects of morphine in renal failure is believed to be caused by a buildup of the active 6-glucuronide metabolite, which depends on renal function for elimination.

6211-15-0, Morphine Sulfate Verwandte Suche:

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