3-cyanoalanine

3-cyanoalanine Chemische Eigenschaften,Einsatz,Produktion Methoden

• Definition

  ChEBI: 3-cyanoalanine is an alanine derivative obtained by replacement of one of the methyl hydrogens in alanine with a cyano group It is an alanine derivative, an aliphatic nitrile and a non-proteinogenic alpha-amino acid.

• Synthesis Reference(s)

  Tetrahedron, 22, p. 2303, 1966 DOI: 10.1016/S0040-4020(01)82149-9

• Stoffwechsel

  In the living plant, 3-cyanoalanine is mainly bound as its gama-glutamyl derivative. The enzyme, beta-cyanoalanine synthase, catalysing the reaction between cysteine and cyanide has been isolated from seedlings of the blue lupin (Lupinus angustifolius, Leguminosae).
  3-Cyanoalanine is a neurotoxin, causing convulsions and muscular rigidity in rats and chicks. In rats, the compound also causes cystathioninuria, the lethai dose being 20mg/100g body weight. This metabolic defect can be prevented by injection of pyridoxal phosphate. Thus, beta-cyanoalanine interferes with pyridoxal metabolism and inhibits the enzyme gama-cystathionase.
  In non-accumulating plants, 3-cyanoalanine is enzymatically hydrolysed to the protein amino acid, asparagine, by 3-cyanoalanine hydrolase. Thus, this nonprotein amino acid could be a ubiquitous constituent of plants, but may only accumulate in those species whieh do not contain 3-cyanoalanine hydrolase.

3-cyanoalanine Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

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